Bobeica Carmen, Niculet Elena, Craescu Mihaela, Parapiru Elena-Laura, Musat Carmina Liana, Dinu Ciprian, Chiscop Iulia, Nechita Luiza, Stefanescu Victorita, Stefanopol Ioana Anca, Pelin Ana Maria, Nechifor Alexandru, Balan Gabriela, Tatu Alin Laurentiu
Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, "Dunărea de Jos" University, Galați, Romania.
Multidisciplinary Integrated Center of Dermatological Interface Research MIC-DIR (Centrul Integrat Multidisciplinar de Cercetare de Interfata Dermatologica - CIM-CID), 'Dunărea de Jos' University, Galați, Romania.
Clin Cosmet Investig Dermatol. 2022 May 30;15:967-973. doi: 10.2147/CCID.S356818. eCollection 2022.
Systemic sclerosis (SSc) is a collagenosis with a substrate of chronic inflammation, which is determined by autoimmunity. The pathogenesis of this disease involves microvasculopathy (small vessel pathology) followed by excessive cutaneous and visceral fibrosis. Although acoustic and vestibular impairment is not classified as being a secondary pathology of SSc, several studies have identified cases of SSc that associate hearing loss and especially vertigo and tinnitus. This paper presents data from the medical literature that have identified vestibular and auditory symptoms among patients with SSc, associating the clinical case presentation of a patient suffering from SSc, which is associated with hearing loss. The need for additional studies on larger groups of patients is underlined, in order to clarify the impact of vasculopathy and fibrosis on the acoustic and vestibular analyzer in patients with SSc.
系统性硬化症（SSc）是一种以慢性炎症为基础的胶原病，由自身免疫决定。该疾病的发病机制涉及微血管病变（小血管病理），随后是皮肤和内脏过度纤维化。尽管听觉和前庭功能障碍未被归类为SSc的继发病理，但多项研究已发现SSc患者出现听力损失，尤其是眩晕和耳鸣的病例。本文展示了医学文献中的数据，这些数据确定了SSc患者中的前庭和听觉症状，并结合了一名患有与听力损失相关的SSc患者的临床病例表现。强调了对更大患者群体进行进一步研究的必要性，以阐明血管病变和纤维化对SSc患者听觉和前庭分析器的影响。
