鼻息肉组织中的自由基损伤。
Free radical damage in nasal polyp tissue.
作者信息
Doğru H, Delibaş N, Döner F, Tüz M, Uygur K
机构信息
ENT-Head and Neck Surgery Department and Biochemistry Department, Süleyman Demirel University, School of Medicine, Isparta, Turkey.
出版信息
Otolaryngol Head Neck Surg. 2001 May;124(5):570-2. doi: 10.1067/mhn.2001.115086.
OBJECTIVE
To investigate whether the free radical injury in nasal polyp tissue exists or not.
STUDY DESIGN
A prospective study in patients with nasal polyps.
METHODS
Polyp specimens were obtained from 19 patients. Control specimens were acquired from 16 patients who underwent partial turbinectomy with concha bullosa free of rhinitis, sinusitis, and allergy, confirmed by endoscopic nasal examination, coronal paranasal sinus CT scan, and prick test. MDA levels of nasal polyps and control specimens were measured by using the method of Knudsen et al.
RESULTS
The mean MDA levels of nasal polyps and control specimens were 38.2 +/- 5.1 (33.3-52.2) and 33.9 +/- 1.6 (32.6-37.4), respectively. MDA levels in NP were significantly higher compared with control specimens (P < 0.01).
CONCLUSION
High level of MDA in nasal polyp tissue that represents FR increase supports the existence of cell injury in nasal polyp tissue. FRs should be considered in the development and life cycles of NP which is thought to have multifactorial pathogenesis.
目的
探讨鼻息肉组织中是否存在自由基损伤。
研究设计
对鼻息肉患者进行前瞻性研究。
方法
从19例患者获取息肉标本。对照标本取自16例行部分鼻甲切除术且无鼻炎、鼻窦炎及过敏的泡状鼻甲患者，经鼻内镜检查、冠状位鼻窦CT扫描及点刺试验证实。采用Knudsen等人的方法测量鼻息肉和对照标本的丙二醛（MDA）水平。
结果
鼻息肉和对照标本的平均MDA水平分别为38.2±5.1（33.3 - 52.2）和33.9±1.6（32.6 - 37.4）。与对照标本相比，鼻息肉中的MDA水平显著更高（P < 0.01）。
结论
鼻息肉组织中高水平的MDA代表自由基增加，支持鼻息肉组织中存在细胞损伤。自由基应在被认为具有多因素发病机制的鼻息肉的发生发展及生命周期中予以考虑。
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