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髓过氧化物酶在鼻息肉发病机制中的表达

Myeloperoxydase expression in the pathogenesis of nasal polyps.

作者信息

Sarisoy Burcin A, Eken Mehmet, Oktay Alev Z, Paksoy Mustafa, Sanli Arif

出版信息

Indian J Otolaryngol Head Neck Surg. 2011 Jul;63(3):260-3. doi: 10.1007/s12070-011-0165-2. Epub 2011 Apr 13.

DOI:10.1007/s12070-011-0165-2
PMID:22754806
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3138963/
Abstract

Nasal polyps are benign mucosal protrusions that expand into the nasal cavity. There are no any etiological factors that may explain the pathogenesis of nasal polyps but currently inflammation continues to be the major factor. As a result of inflammation, neutrophils become activated and migrate to the inflammatory area and form their bactericidal effects by producing free oxygen radicals. The objective of our study is to investigate the expression of myeloperoxydase enzyme, which is usually an indicator of leukocyte infiltration and is responsible in the formation of free oxygen radicals in polyp tissues and to determine its role in the pathogenesis of nasal polyps.

摘要

鼻息肉是向鼻腔内突出的良性黏膜肿物。目前尚无任何病因学因素能够解释鼻息肉的发病机制，但炎症仍是主要因素。炎症会激活中性粒细胞，使其迁移至炎症区域，并通过产生氧自由基发挥杀菌作用。我们研究的目的是探究髓过氧化物酶的表达情况，该酶通常是白细胞浸润的指标，且在息肉组织中氧自由基的形成过程中发挥作用，同时确定其在鼻息肉发病机制中的作用。

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