Toronov V, Webb A, Choi J H, Wolf M, Michalos A, Gratton E, Hueber D
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign 61801, USA.
Med Phys. 2001 Apr;28(4):521-7. doi: 10.1118/1.1354627.
The aim of this study was to compare functional cerebral hemodynamic signals obtained simultaneously by near infrared spectroscopy (NIRS) and by functional magnetic resonance imaging (fMRI). The contribution of superficial layers (skin and skull) to the NIRS signal was also assessed. Both methods were used to generate functional maps of the motor cortex area during a periodic sequence of stimulation by finger motion and rest. In all subjects we found a good collocation of the brain activity centers revealed by both methods. We also found a high temporal correlation between the BOLD signal (fMRI) and the deoxy-hemoglobin concentration (NIRS) in the subjects who exhibited low fluctuations in superficial head tissues.
本研究的目的是比较通过近红外光谱（NIRS）和功能磁共振成像（fMRI）同时获得的大脑功能血流动力学信号。还评估了表层（皮肤和颅骨）对NIRS信号的贡献。在手指运动和休息的周期性刺激序列期间，两种方法都用于生成运动皮层区域的功能图。在所有受试者中，我们发现两种方法揭示的大脑活动中心有很好的匹配。我们还发现，在头部表层组织波动较小的受试者中，血氧水平依赖（BOLD）信号（fMRI）与脱氧血红蛋白浓度（NIRS）之间存在高度的时间相关性。
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