Chiossi M P, Roselino A M
Division of Dermatology, Department of Medical Clinics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, SP, Brazil.
Rev Inst Med Trop Sao Paulo. 2001 Mar-Apr;43(2):59-62. doi: 10.1590/s0036-46652001000200001.
Endemic Pemphigus Foliaceus (EPF) is a bullous autoimmune skin disease whose incidence used to be high in the State of São Paulo (SP), Brazil, during the forties, but has declined thereafter.
to report a series of EPF patients from the northeastern region of SP.
a retrospective study concerning demographic and epidemiological data of patients seen from 1973 to 1998 was conducted at the University Hospital, Faculty of Medicine of Ribeirão Preto, SP.
bullous disease was diagnosed in 340 patients, 245 with EPF (72.1%), 9.4 cases per year, 60.4% females, and 70.2% white, 7 to 82 year-old (29.4% in their teens); 46.9% lived in the rural zone. Concerning profession, housewives predominated among women (67.6%) and agricultural workers among men (40.2%). The time of disease was less than 1 year in 62.0% of cases, followed by 1 and 5 years (27%), and more than 5 years for the remaining patients (11%). 36.7% of patients were referred by the Direção Regional de Saúde (DIR) XVIII of Ribeirão Preto, with the largest number of cases being from Ribeirão Preto and Batatais: 33.3% and 23.3%, respectively; 22% from DIR XIII (Franca); 13.5% from DIR VII (Araraquara); 2.9% from DIR IX (Barretos); 4.1% from other DIRs of SP, and 20.8% from other States (16.7% from Minas Gerais). Thirteen (5.3%) patients reported occurrence of the disease in some relative, and 4 (1.6%) in neighbors.
the present data characterize the northeastern region of the state of São Paulo as a remaining endemic focus of EPF.
地方性落叶性天疱疮（EPF）是一种大疱性自身免疫性皮肤病，在20世纪40年代，巴西圣保罗州（SP）的发病率曾很高，但此后有所下降。
报告一系列来自圣保罗州东北部地区的EPF患者。
在圣保罗州里贝朗普雷图医学院大学医院对1973年至1998年期间就诊患者的人口统计学和流行病学数据进行了一项回顾性研究。
340例患者被诊断为大疱性疾病，其中245例为EPF（72.1%），每年9.4例，女性占60.4%，白人占70.2%，年龄在7至82岁之间（青少年占29.4%）；46.9%居住在农村地区。职业方面，女性中家庭主妇占主导（67.6%），男性中农业工人占主导（40.2%）。62.0%的病例病程少于1年，其次是1至5年（27%），其余患者病程超过5年（11%）。36.7%的患者由里贝朗普雷图第十八地区卫生局（DIR）转诊，病例数最多的是里贝朗普雷图和巴塔伊斯：分别占33.3%和23.3%；22%来自第十三地区卫生局（弗朗卡）；13.5%来自第七地区卫生局（阿拉拉夸拉）；2.9%来自第九地区卫生局（巴雷图斯）；4.1%来自圣保罗州的其他地区卫生局，20.8%来自其他州（16.7%来自米纳斯吉拉斯州）。13例（5.3%）患者报告其亲属中有人患此病，4例（1.6%）患者报告邻居中有人患此病。
目前的数据表明，圣保罗州东北部地区仍是EPF的地方性疫源地。
