Musil D
II. interní klinika LF a FN, Olomouc.
Vnitr Lek. 2000 Oct;46(10):728-31.
The author describes a case of early onset of asymptomatic renal insufficiency in a young patient with ulcerative colitis, treated by large doses of mesalazine. After discontinuation of the drug rapid restoration of renal functions occurred. Contrary to all hitherto published cases, this patient developed renal failure very soon. Urea serum levels reached pathological values after 27 days and the creatinine level already 15 days after the onset of mesalazine administration. The renal affection was unequivocally confirmed by examination of the urine (semiquantitative and quantitative) and dynamic functional scintigraphy.
作者描述了一名患有溃疡性结肠炎的年轻患者在大剂量服用美沙拉嗪后出现早期无症状肾功能不全的病例。停药后肾功能迅速恢复。与迄今为止所有已发表的病例相反，该患者很快就出现了肾衰竭。服用美沙拉嗪27天后血清尿素水平达到病理值，肌酐水平在服用美沙拉嗪15天后就已升高。通过尿液检查（半定量和定量）以及动态功能闪烁扫描明确证实了肾脏病变。
