De Laey J J
Departement d'Ophtalmologie, Hôpital Universitaire de Gand, De Pintelaan, 185, Gand.
Bull Soc Belge Ophtalmol. 2001(279):81-9.
Intraocular non-Hodgkin lymphoma often masquerades a chronic uveitis, which does however not respond to local and/or systemic immunosuppressive treatment. The anterior segment signs are usually discrete, although a hypopion may appear during evolution. The vitreous is often markedly involved. The chorioretinal lesions are variable in aspect. Subretinal infiltrates or solid retinal pigment epithelial detachments are the most characteristic fundus signs of the disease. Other fundus signs may be present, such as retinal vascular occlusions, perivasculitis, macular oedema, optic disc oedema or ischaemic optic neuropathy. The diagnosis is based on histological or cytological examination of anterior chamber material in case of hypopion, or more frequently from vitrectomy specimens or from direct biopsy of suspected fundus lesions. Polymerase chain reaction and flow cytometry can be extremely helpful in the diagnosis of intraocular lymphoma when the cytology is not conclusive.
眼内非霍奇金淋巴瘤常伪装成慢性葡萄膜炎，然而，这种疾病对局部和/或全身免疫抑制治疗无反应。前段体征通常不明显，尽管在病程中可能会出现前房积脓。玻璃体常明显受累。脉络膜视网膜病变外观多样。视网膜下浸润或实性视网膜色素上皮脱离是该疾病最具特征性的眼底体征。其他眼底体征也可能出现，如视网膜血管阻塞、血管周围炎、黄斑水肿、视盘水肿或缺血性视神经病变。诊断基于在前房积脓情况下对前房材料进行组织学或细胞学检查，更常见的是通过玻璃体切除标本或对疑似眼底病变进行直接活检。当细胞学检查结果不明确时，聚合酶链反应和流式细胞术对眼内淋巴瘤的诊断可能非常有帮助。
