Keshavarzi A, Vaezy S, Kaczkowski P J, Keilman G, Martin R, Chi E Y, Garcia R, Fujimoto V Y
Department of Bioengineering, University of Washington, Seattle 98195, USA.
J Ultrasound Med. 2001 May;20(5):473-80. doi: 10.7863/jum.2001.20.5.473.
To develop a noninvasive method for treatment of uterine fibroid tumors using high-intensity focused ultrasound. Optimal high-intensity focused ultrasound treatment would be dependent on quantitative information about ultrasonic tissue characteristics.
Ultrasonic attenuation and the sound speed of fresh human fibroid tumors and myometrium were measured as a function of frequency (1-3 MHz) by using a pulse transmission technique before and after in vitro high-intensity focused ultrasound treatment (3.5 MHz at an intensity of 2,000 W/cm2).
The ranges of the attenuation coefficients, before and after high-intensity focused ultrasound treatment, were 0.9 to 2.2 and 1.8 to 3.9 dB/cm2, respectively, for fibroid tumors and 0.5 to 1.6 and 1.7 to 3.3 dB/cm2, respectively, for myometrium. Although the sound speed appeared to be independent of frequency (1,611 to 1,616 m/s at 1 to 3 MHz) in both types of tissues, a slight increase of approximately 4 to 14 m/s was observed after high-intensity focused ultrasound treatment.
The results of this study represent our first reported values of the attenuation coefficient and sound speed in fibroid tumors and myometrium before and after high-intensity focused ultrasound treatment.
开发一种使用高强度聚焦超声治疗子宫肌瘤的非侵入性方法。最佳的高强度聚焦超声治疗将依赖于有关超声组织特征的定量信息。
在体外高强度聚焦超声治疗（3.5MHz，强度为2000W/cm²）前后，通过脉冲传输技术测量新鲜人子宫肌瘤和子宫肌层的超声衰减和声速随频率（1-3MHz）的变化。
高强度聚焦超声治疗前后，子宫肌瘤的衰减系数范围分别为0.9至2.2dB/cm²和1.8至3.9dB/cm²，子宫肌层的衰减系数范围分别为0.5至1.6dB/cm²和1.7至3.3dB/cm²。虽然两种组织中的声速似乎与频率无关（1至3MHz时为1611至1616m/s），但在高强度聚焦超声治疗后观察到声速略有增加，约为4至14m/s。
本研究结果代表了我们首次报道的高强度聚焦超声治疗前后子宫肌瘤和子宫肌层的衰减系数和声速值。
