Drakos Theocharis, Antoniou Anastasia, Evripidou Nikolas, Alecou Tereza, Giannakou Marinos, Menikou Georgios, Constantinides Georgios, Damianou Christakis
MEDSONIC LTD, Limassol, Cyprus.
Department of Electrical Engineering, Computer Engineering, and Informatics, Cyprus University of Technology, Limassol, Cyprus.
J Med Ultrasound. 2021 May 31;29(4):239-249. doi: 10.4103/JMU.JMU_145_20. eCollection 2021 Oct-Dec.
It has been demonstrated that agar-based gel phantoms can emulate the acoustic parameters of real tissues and are the most commonly used tissue-mimicking materials for high-intensity focused ultrasound applications. The following study presents ultrasonic attenuation measurements of agar-based phantoms with different concentrations of additives (percent of agar, silicon dioxide and evaporated milk) in an effort of matching the material's acoustic property as close as possible to human tissues.
Nine different agar-based phantoms with various amounts of agar, silicon dioxide, and evaporated milk were prepared. Attenuation measurements of the samples were conducted using the through-transmission immersion techniques.
The ultrasonic attenuation coefficient of the agar-based phantoms varied in the range of 0.30-1.49 dB/cm-MHz. The attenuation was found to increase in proportion to the concentration of agar and evaporated milk. Silicon dioxide was found to significantly contribute to the attenuation coefficient up to 4% weight to volume (w/v) concentration.
The acoustic attenuation coefficient of agar-based phantoms can be adjusted according to the tissue of interest in the range of animal and human tissues by the proper selection of agar, silicon dioxide, and evaporated milk.
已证明基于琼脂的凝胶体模可以模拟真实组织的声学参数，并且是高强度聚焦超声应用中最常用的组织模拟材料。以下研究展示了对含有不同浓度添加剂（琼脂、二氧化硅和蒸发乳的百分比）的基于琼脂的体模的超声衰减测量，旨在使材料的声学特性尽可能接近人体组织。
制备了九种含有不同量琼脂、二氧化硅和蒸发乳的基于琼脂的体模。使用穿透传输浸入技术对样品进行衰减测量。
基于琼脂的体模的超声衰减系数在0.30 - 1.49 dB/cm-MHz范围内变化。发现衰减与琼脂和蒸发乳的浓度成正比。发现二氧化硅在重量体积比（w/v）浓度高达4%时对衰减系数有显著贡献。
通过适当选择琼脂、二氧化硅和蒸发乳，可以在动物和人体组织范围内根据感兴趣的组织调整基于琼脂的体模的声衰减系数。
