Yamaguchi M, Ohno T, Miyata E, Toyoda H, Nishii K, Masuya M, Kita K, Shiku H
Second Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
Int J Hematol. 2001 Apr;73(3):383-5. doi: 10.1007/BF02981966.
We report a case of concomitant mantle cell lymphoma (MCL) and multiple myeloma (MM) in which we investigated the possibility of a clonal relationship. A 76-year-old man was diagnosed with MCL [immunoglobulin (Ig)M,D-kappa; stage IVB] and MM (IgG-kappa; stage I). Ig heavy chain (IgH) gene complementarity-determining region 3 in DNA from both the MCL tumor and from single MM cells from bone marrow smears was amplified to investigate whether there was a clonal relationship between MCL and MM. Sequence analysis revealed no clonal relationship between MCL and MM in our patient.
我们报告了一例套细胞淋巴瘤（MCL）与多发性骨髓瘤（MM）并存的病例，并对两者之间的克隆关系可能性进行了研究。一名76岁男性被诊断为MCL[免疫球蛋白（Ig）M，D-κ；IVB期]和MM（IgG-κ；I期）。对MCL肿瘤以及骨髓涂片单个MM细胞的DNA中的Ig重链（IgH）基因互补决定区3进行扩增，以研究MCL与MM之间是否存在克隆关系。序列分析显示，我们的患者中MCL与MM之间不存在克隆关系。
