套细胞淋巴瘤患者新发多发性骨髓瘤：是共同的遗传因素还是单纯巧合？
New diagnosis of multiple myeloma in a patient with mantle cell lymphoma: Shared genetic factors or simple coincidence?
作者信息
Sikuyayenga Mutende J, Reeder Craig B, Mikhael Joseph R
机构信息
Division of Hematology-Oncology, Mayo Clinic, Scottsdale, AZ, United States.
出版信息
Leuk Res Rep. 2012 Nov 10;1(1):7-8. doi: 10.1016/j.lrr.2012.09.003. eCollection 2012.
Abstract
Multiple Myeloma and Mantle Cell Lymphoma are well defined hematological malignancies. Understanding of their pathogeneses has led to new therapies and increased survival. We report on a 64-yr-old female who was diagnosed with mantle cell lymphoma in 2003, then multiple myeloma in 2010. We identified only few other cases of concomitant MM and MCL. We also explored the importance of t(11;14)(q13;q32). The development of these two disorders in the same patient may simply be due to chance; however, it may also represent a common genetic hit affecting the B-cell population leading to development of two different malignancies.
摘要
多发性骨髓瘤和套细胞淋巴瘤是明确的血液系统恶性肿瘤。对其发病机制的了解带来了新的治疗方法并提高了生存率。我们报告了一名64岁女性，她于2003年被诊断为套细胞淋巴瘤，2010年又被诊断为多发性骨髓瘤。我们仅发现了其他少数几例同时患有多发性骨髓瘤和套细胞淋巴瘤的病例。我们还探讨了t(11;14)(q13;q32)的重要性。这两种疾病在同一患者体内的发生可能仅仅是偶然；然而，它也可能代表一种影响B细胞群体的共同基因打击，导致两种不同恶性肿瘤的发生。
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