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脂质体两性霉素B联合手术成功治疗1例急性T淋巴细胞白血病合并侵袭性肺毛霉病患者

Liposomal amphotericin B and surgery in the successful treatment of invasive pulmonary mucormycosis in a patient with acute T-lymphoblastic leukemia.

作者信息

Björkholm M, Runarsson G, Celsing F, Kalin M, Petrini B, Engervall P

机构信息

Department of Medicine, Karolinska Hospital, Stockholm, Sweden.

出版信息

Scand J Infect Dis. 2001;33(4):316-9. doi: 10.1080/003655401300077469.

DOI:10.1080/003655401300077469
PMID:11345227
Abstract

Pulmonary mucormycosis is a usually fatal opportunistic infection in immunocompromised patients. We describe the first case of an adult patient with hematological malignancy and profound neutropenia to survive a disseminated pulmonary Rhizomucor pusillus infection. Early diagnostic procedures combined with high doses of liposomal amphotericin B and surgical resection may have contributed to the successful outcome.

摘要

肺毛霉菌病是免疫功能低下患者中一种通常致命的机会性感染。我们描述了首例患有血液系统恶性肿瘤且严重中性粒细胞减少的成年患者,其成功存活于播散性微小根毛霉感染。早期诊断程序联合高剂量脂质体两性霉素B及手术切除可能促成了这一成功结果。

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