Markowitz G S
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA.
Adv Anat Pathol. 2001 May;8(3):119-25. doi: 10.1097/00125480-200105000-00001.
Membranous glomerulopathy (MGN) is characterized by subepithelial immune complex deposits and glomerular basement membrane (GBM) thickening. The majority of patients present with nephrotic syndrome and outcomes are variable. Pathologically, deposits at sites other than the subepithelial aspect of the GBM favor the presence of secondary forms of MGN which are seen most commonly in the setting of autoimmune disease, infection, neoplasia, and with certain therapeutic agents. MGN is the most common form of de novo glomerular disease seen in the renal allograft and may be seen concurrently with other forms of glomerular disease including focal segmental glomerulosclerosis, IgA nephropathy, diabetic nephropathy, and anti-TBM nephritis. This review emphasizes the detection of secondary forms and variants of MGN.
膜性肾小球病（MGN）的特征是上皮下免疫复合物沉积和肾小球基底膜（GBM）增厚。大多数患者表现为肾病综合征，预后各不相同。病理上，GBM上皮下以外部位的沉积物提示存在继发性MGN，最常见于自身免疫性疾病、感染、肿瘤以及某些治疗药物的情况下。MGN是肾移植中最常见的新发肾小球疾病形式，可能与其他形式的肾小球疾病同时出现，包括局灶节段性肾小球硬化、IgA肾病、糖尿病肾病和抗TBM肾炎。本综述着重于继发性MGN形式和变异型的检测。
