Norris C R, Griffey S M, Samii V F, Christopher M M, Mellema M S
Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616-8734, USA.
J Am Vet Med Assoc. 2001 May 1;218(9):1456-61. doi: 10.2460/javma.2001.218.1456.
To compare results of thoracic radiography, cytologic evaluation of bronchoalveolar lavage (BAL) fluid, and histologic evaluation of biopsy and necropsy specimens in dogs with respiratory tract disease and to determine whether histologic evaluation provides important diagnostic information not attainable by the other methods.
Retrospective study.
16 dogs.
BAL fluid was classified as normal, neutrophilic, eosinophilic, mononuclear, mixed, neoplastic, or nondiagnostic. Radiographic abnormalities were classified as interstitial, bronchial, bronchointerstitial, or alveolar. Histologic lesions were classified as inflammatory, fibrotic, or neoplastic, and the predominant site of histologic lesions was classified as the alveoli, interstitium, or airway.
The predominant radiographic location of lesions correlated with the histologic location in 8 dogs. Of 11 dogs with histologic evidence of inflammatory disease, 8 had inflammatory BAL fluid. Of the 2 dogs with histologic evidence of neoplasia, 1 had BAL fluid suggestive of neoplasia, and the other had BAL fluid consistent with septic purulent inflammation. Two dogs without any histologic abnormalities had mononuclear or nondiagnostic BAL fluid. Two dogs with histologic evidence of fibrosis had mononuclear or mixed inflammatory BAL fluid.
Results suggest that although thoracic radiography, cytologic evaluation of BAL fluid, and histologic evaluation of lung specimens are complementary, each method has limitations in regard to how well results reflect the underlying disease process in dogs with respiratory tract disease. Lung biopsy should be considered in cases where results of radiography and cytology are nondiagnostic.
比较胸部放射成像、支气管肺泡灌洗（BAL）液的细胞学评估以及患有呼吸道疾病犬只的活检和尸检标本的组织学评估结果，并确定组织学评估是否能提供其他方法无法获得的重要诊断信息。
回顾性研究。
16只犬。
BAL液被分类为正常、嗜中性、嗜酸性、单核、混合性、肿瘤性或无法诊断。放射学异常被分类为间质性、支气管性、支气管间质性或肺泡性。组织学病变被分类为炎症性、纤维化或肿瘤性，组织学病变的主要部位被分类为肺泡、间质或气道。
8只犬的病变主要放射学位置与组织学位置相关。在11只具有炎症性疾病组织学证据的犬中，8只BAL液为炎症性。在2只具有肿瘤形成组织学证据的犬中，1只BAL液提示肿瘤形成，另1只BAL液与脓毒性化脓性炎症一致。2只无任何组织学异常的犬BAL液为单核或无法诊断。2只具有纤维化组织学证据的犬BAL液为单核或混合性炎症。
结果表明，尽管胸部放射成像、BAL液的细胞学评估以及肺标本的组织学评估是互补的，但每种方法在反映患有呼吸道疾病犬的潜在疾病过程方面都有局限性。在放射学和细胞学结果无法诊断的情况下，应考虑进行肺活检。
