Strenge H
Institut für Medizinische Psychologie der Universität Kiel.
Psychother Psychosom Med Psychol. 2001 Mar-Apr;51(3-4):166-75. doi: 10.1055/s-2001-12378.
The relationship between psychological stress and the course of MS has been investigated in several studies using methods with different qualities. The majority of findings indicates that acute short-term stressors have no negative consequences. Chronic psychosocial stressors, however, such as interpersonal conflicts, loss and complicated bereavement, low perceived social support, anxiety and depressive episodes have to be regarded as possible risk factors for the development of MS exacerbations. The neuroimmunological findings in MS and under various stress conditions are delineated with emphasis on the changes in lymphocyte and cytokine networks and evaluated with regard to their possible clinical significance. Practical consequences for psychological intervention strategies are discussed.
多项研究采用了不同质量的方法对心理压力与多发性硬化症病程之间的关系进行了调查。大多数研究结果表明，急性短期应激源没有负面影响。然而，慢性心理社会应激源，如人际冲突、丧失和复杂的丧亲之痛、低感知社会支持、焦虑和抑郁发作，必须被视为多发性硬化症病情加重的可能风险因素。文中阐述了多发性硬化症以及各种应激条件下的神经免疫学研究结果，重点强调了淋巴细胞和细胞因子网络的变化，并对其可能的临床意义进行了评估。还讨论了心理干预策略的实际影响。
