Melato M, Gorji N, Rizzardi C, Maglione M
Institute of Pathological Anatomy, University of Study, Trieste.
Minerva Stomatol. 2000 Nov-Dec;49(11-12):549-54.
Morphea, lichen planus and vitiligo are common diseases, but seldom associated. Morphea or lichen planus in the lips have not frequently been reported, and an associated localization of both lesions in the lip mucosa is indeed a rare event. A case of morphea and lichen planus localized in the upper lip mucosa in a patient with vitiligo is reported. Immunohistochemistry revealed a clear prevalence of T-lymphocytes in the inflammatory infiltrates of morphea and in the band-like infiltrate of the lichen, a finding consistent with previous reports of morphea, lichen planus, and vitiligo. The inverse ratio found between CD8+ and CD4+ lymphocytes, compared to other reports, seems to confirm that the pathogenesis of morphea and lichen planus evolves through different stages. The present report, besides presenting a rare case, may prompt to consider a common pathogenesis among morphea, lichen planus and vitiligo.
硬斑病、扁平苔藓和白癜风是常见疾病，但很少同时出现。唇部硬斑病或扁平苔藓的报道并不常见，而两种病变同时出现在唇黏膜的情况确实罕见。本文报告了1例白癜风患者上唇黏膜同时出现硬斑病和扁平苔藓的病例。免疫组化显示，硬斑病的炎性浸润及扁平苔藓的带状浸润中T淋巴细胞明显占优势，这一发现与之前关于硬斑病、扁平苔藓和白癜风的报道一致。与其他报道相比，CD8 +和CD4 +淋巴细胞的反比关系似乎证实硬斑病和扁平苔藓的发病机制是通过不同阶段演变的。本报告除了呈现一个罕见病例外，可能会促使人们考虑硬斑病、扁平苔藓和白癜风之间存在共同的发病机制。
