Patricelli M P, Cravatt B F
Skaggs Institute for Chemical Biology and the Department of Cell Biology, Scripps Research Institute, La Jolla, California, USA.
Vitam Horm. 2001;62:95-131. doi: 10.1016/s0083-6729(01)62002-8.
Fatty acid amides (FAAs) represent a growing family of biologically active lipids implicated in a diverse range of cellular and physiological processes. At present, two general types of fatty acid amides, the N-acylethanolamines (NAEs) and the fatty acid primary amides (FAPAs), have been identified as potential physiological neuromodulators/neurotransmitters in mammals. Representative members of these two subfamilies include the endocannabinoid NAE anandamide and the sleep-inducing FAPA oleamide. In this Chapter, molecular mechanisms proposed for the biosynthesis and inactivation of FAAs are critically evaluated, with an emphasis placed on the biochemical and cell biological properties of proteins thought to mediate these processes.
脂肪酸酰胺（FAA）是一类不断增加的具有生物活性的脂质，涉及多种细胞和生理过程。目前，已确定两种常见类型的脂肪酸酰胺，即N-酰基乙醇胺（NAE）和脂肪酸伯酰胺（FAPA），它们在哺乳动物中是潜在的生理神经调节剂/神经递质。这两个亚家族的代表性成员包括内源性大麻素NAE花生四烯乙醇胺和诱导睡眠的FAPA油酰胺。在本章中，对提出的FAA生物合成和失活的分子机制进行了严格评估，重点关注被认为介导这些过程的蛋白质的生化和细胞生物学特性。
