Anisman H, Hayley S, Kelly O, Borowski T, Merali Z
Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
Behav Neurosci. 2001 Apr;115(2):443-54.
The effects of several stressors were assessed in inbred strains of mice, BALB/cByJ and C57BL/6ByJ, thought to be differentially reactive to stressors. Behavioral reactivity was greater in BALB/cByJ mice with respect to open-field emergence, step-down responding, response to a predator (rat) or to fox urine odor. Neurogenic insults (e.g., footshock, forced swim, restraint) and a systemic stressor (intraperitoneal interleukin-1beta treatment) likewise provoked a greater rise of plasma corticosterone in the BALB/cByJ mice. Psychogenic stressors (e.g., novel open-field exposure, acoustic startle stimuli) also enhanced plasma corticosterone to a greater extent in BALB/cByJ mice, but such an outcome was not apparent following predator-related cues. It appears that whereas stressor reactivity and adrenal glucocorticoid release may be exaggerated in BALB/cByJ mice, such effects may be dependent on the specific characteristic of the stressor situation.
在被认为对应激源有不同反应的近交系小鼠BALB/cByJ和C57BL/6ByJ中评估了几种应激源的影响。在旷场出现、跳台反应、对捕食者（大鼠）或狐狸尿液气味的反应方面，BALB/cByJ小鼠的行为反应性更强。神经源性损伤（如电击足底、强迫游泳、束缚）和全身性应激源（腹腔注射白细胞介素-1β）同样在BALB/cByJ小鼠中引起血浆皮质酮水平更大幅度的升高。心理性应激源（如新奇旷场暴露、听觉惊吓刺激）在BALB/cByJ小鼠中也能更大程度地提高血浆皮质酮水平，但在与捕食者相关的线索刺激后，这种结果并不明显。似乎虽然BALB/cByJ小鼠的应激源反应性和肾上腺糖皮质激素释放可能会被夸大，但这种影响可能取决于应激源情况的具体特征。
