Lu Z W, Song C, Ravindran A V, Merali Z, Anisman H
Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
Brain Behav Immun. 1998 Mar;12(1):7-22. doi: 10.1006/brbi.1997.0510.
It is demonstrated that cell proliferation in response to mitogens, natural killer cell (NK) activity, and macrophage functioning of mice may be influenced by either a neurogenic stressor (footshock) or a psychogenic stressor (exposing the mouse to a predator, namely a rat). The nature and magnitude of the immune changes, however, varied across three strains of mice (BALB/cByJ, C57BL/6ByJ, and CD-1), differing in reactivity to stressors and also as a function of the type of stressor employed. While footshock reduced mitogen-stimulated B-cell proliferation in BALB/cByJ mice, it had the opposite effect in the CD-1 strain. Exposure to the predator, however, had little effect in any of the strains. Macrophage activity and NK cytotoxicity were reduced in response to both stressors in a strain-dependent fashion. Plasma corticosterone in response to footshock was greater in BALB/cByJ than in C57BL/6ByJ mice; however, the strain difference was not evident in response to the psychogenic stressor. It is suggested that analyses of stressor effects on immune functioning need to consider the specific strain/species employed, the particular immune parameters being examined, and the nature of the stressor employed.
研究表明，有丝分裂原刺激的细胞增殖、自然杀伤细胞（NK）活性以及小鼠的巨噬细胞功能，可能会受到神经源性应激源（足部电击）或心理性应激源（将小鼠暴露于捕食者，即大鼠）的影响。然而，免疫变化的性质和程度在三种小鼠品系（BALB/cByJ、C57BL/6ByJ和CD-1）中有所不同，这三种品系对应激源的反应性不同，并且也是所采用应激源类型的函数。虽然足部电击降低了BALB/cByJ小鼠中有丝分裂原刺激的B细胞增殖，但在CD-1品系中却产生了相反的效果。然而，暴露于捕食者对任何品系的影响都很小。巨噬细胞活性和NK细胞毒性以品系依赖的方式对应激源作出反应而降低。BALB/cByJ小鼠对足部电击的血浆皮质酮反应比对C57BL/6ByJ小鼠更强；然而，在心理性应激源的反应中，品系差异并不明显。建议对应激源对免疫功能影响的分析需要考虑所采用的特定品系/物种、所检查的特定免疫参数以及所采用应激源的性质。
