Divaris Dimitrios X. G., Smith Sharyn, Leask David, Troster Michael, O'Malley Frances P.
Departments of Pathology and Surgery, Grand River Hospital, Kitchener, Ontario, Canada, and Department of Pathology, London Health Sciences Centre, London, Ontario, Canada.
Breast J. 2000 May;6(3):199-203. doi: 10.1046/j.1524-4741.2000.98043.x.
Collagenous spherulosis is a rare, benign breast lesion occuring in less than 1% of benign breast biopsies. All previously reported cases have been discovered as incidental microscopic findings in association with a range of benign to malignant processes. The authors report the first case of collagenous spherulosis presenting as a palpable mass. Immunohistochemistry and electron microscopy performed on this lesion demonstrated the presence of two cell types: epithelial cells and myoepithelial cells with associated basement membranelike material. Collagenous spherulosis may mimic adenoid cystic carcinoma since the epithelial proliferation and spherule formation in collagenous spherulosis closely resembles the changes in adenoid cystic carcinoma. However, adenoid cystic carcinoma is an invasive lesion that is almost always palpable, while collagenous spherulosis is almost always an incidental microscopic finding. Our case illustrates that collagenous spherulosis can also result in a palpable mass, thus palpability of the lesion cannot be used to differentiate these conditions.
胶原球病是一种罕见的良性乳腺病变，在不到1%的良性乳腺活检中出现。所有先前报道的病例都是在与一系列良性至恶性病变相关的偶然显微镜检查中发现的。作者报告了首例表现为可触及肿块的胶原球病病例。对该病变进行的免疫组织化学和电子显微镜检查显示存在两种细胞类型：上皮细胞和肌上皮细胞，并伴有基底膜样物质。胶原球病可能会模仿腺样囊性癌，因为胶原球病中的上皮增生和小球形成与腺样囊性癌的变化非常相似。然而，腺样囊性癌是一种几乎总是可触及的浸润性病变，而胶原球病几乎总是偶然的显微镜检查发现。我们的病例表明，胶原球病也可导致可触及的肿块，因此病变的可触及性不能用于区分这些情况。
