Grignon D J, Ro J Y, Mackay B N, Ordóñez N G, Ayala A G
Department of Pathology, U.T. M.D. Anderson Cancer Center, Houston 77030.
Am J Clin Pathol. 1989 Apr;91(4):386-92. doi: 10.1093/ajcp/91.4.386.
Collagenous spherulosis of the breast is a recently described benign breast lesion that has previously been seen only incidentally. The authors report two cases of this lesion studied by immunohistochemistry and electron microscopy and a third case studied by light microscopy alone. The results demonstrate the participation of two cell types in the process: myoepithelial cells, which stained positively for cytokeratin, S-100 protein, and muscle-specific actin and contained intermediate filaments with dense bodies, pinocytotic vesicles, and formed cell junctions; and epithelial cells, which reacted for cytokeratin but not for S-100 protein or muscle-specific actin and contained intracytoplasmic lumina, formed lumina with microvilli, and desmosomes. Material constituting the spherules stained intensely for type IV collagen, and its ultrastructure was similar to that of basement-membrane material. The authors conclude that collagenous spherulosis results from a proliferation of epithelial and myoepithelial cells, the latter of which produce basement-membrane material.
乳腺胶原小球病是一种最近才被描述的良性乳腺病变，此前仅偶然被发现。作者报告了两例通过免疫组织化学和电子显微镜研究的该病变病例，以及另一例仅通过光学显微镜研究的病例。结果表明，在这个过程中有两种细胞类型参与：肌上皮细胞，其细胞角蛋白、S-100蛋白和肌肉特异性肌动蛋白染色呈阳性，含有带致密小体的中间丝、吞饮小泡，并形成细胞连接；上皮细胞，其细胞角蛋白呈阳性反应，但S-100蛋白或肌肉特异性肌动蛋白呈阴性反应，含有胞质内管腔，形成有微绒毛的管腔和桥粒。构成小球的物质IV型胶原染色强烈，其超微结构与基底膜物质相似。作者得出结论，乳腺胶原小球病是上皮细胞和肌上皮细胞增殖的结果，后者产生基底膜物质。
