Clement P B, Young R H, Azzopardi J G
Am J Surg Pathol. 1987 Jun;11(6):411-7. doi: 10.1097/00000478-198706000-00001.
Fifteen examples of a hitherto undescribed lesion, which we have designated "collagenous spherulosis," were encountered in breast tissue from women aged 39 to 55 years. The lesion, which was multifocal in eight cases, was an incidental microscopic finding involving lobular acini and ductules, and consisted of intraluminal clusters of eosinophilic spherules measuring approximately 20-100 mu in diameter. The spherules typically were found, and appeared to originate, within the spaces of fenestrated epitheliosis ("papillomatosis"). Special stains indicated that the spherules were collagen-rich, but also contained variable amounts of acidic mucin, PAS-positive, basement membrane-like material, and elastin. With immunoperoxidase staining, the cells immediately surrounding the spherules stained positively for actin, suggesting myoepithelial differentiation. Collagenous spherulosis was typically situated adjacent to, or encompassed by, other benign proliferative processes, including intraductal papillomas, sclerosing adenosis, and "infiltrating epitheliosis" (radial scars). Collagenous spherulosis is a clinically and histologically benign lesion that on microscopic examination has been confused with--and should be distinguished from--malignant lesions including adenoid cystic carcinoma of the breast and so-called intraductal signet-ring carcinoma.
在39至55岁女性的乳腺组织中发现了15例一种此前未被描述的病变，我们将其命名为“胶原球状体病”。该病变在8例中为多灶性，是一种偶然的显微镜下发现，累及小叶腺泡和小导管，由直径约20 - 100微米的嗜酸性球状体腔内簇组成。球状体通常在开窗性上皮增生（“乳头状瘤病”）的间隙中发现，且似乎起源于此。特殊染色显示球状体富含胶原蛋白，但也含有不同量的酸性粘蛋白、PAS阳性的基底膜样物质和弹性蛋白。免疫过氧化物酶染色显示，球状体周围的细胞肌动蛋白染色呈阳性，提示有肌上皮分化。胶原球状体病通常位于其他良性增生性病变附近或被其包围，包括导管内乳头状瘤、硬化性腺病和“浸润性上皮增生”（放射状瘢痕）。胶原球状体病是一种临床和组织学上的良性病变，在显微镜检查中曾与包括乳腺腺样囊性癌和所谓导管内印戒细胞癌在内的恶性病变相混淆，应予以鉴别。
