Robinson H L, Montefiori D C, Johnson R P, Manson K H, Kalish M L, Lifson J D, Rizvi T A, Lu S, Hu S L, Mazzara G P, Panicali D L, Herndon J G, Glickman R, Candido M A, Lydy S L, Wyand M S, McClure H M
Yerkes Regional Primate Research Center, Atlanta, Georgia 30329, USA.
Nat Med. 1999 May;5(5):526-34. doi: 10.1038/8406.
Eight different protocols were compared for their ability to raise protection against immunodeficiency virus challenges in rhesus macaques. The most promising containment of challenge infections was achieved by intradermal DNA priming followed by recombinant fowl pox virus booster immunizations. This containment did not require neutralizing antibody and was active for a series of challenges ending with a highly virulent virus with a primary isolate envelope heterologous to the immunizing strain.
对八种不同的方案进行了比较，以评估它们在恒河猴中增强针对免疫缺陷病毒攻击的保护能力。通过皮内注射DNA进行初次免疫，随后用重组鸡痘病毒进行加强免疫，实现了对攻击感染最有前景的控制。这种控制不需要中和抗体，并且对一系列攻击有效，这些攻击以一种具有与免疫菌株异源的原始分离株包膜的高毒力病毒结束。
