HLA-DBR 1等位基因与伊朗乳腺癌患者的易感性

HLA-DBR 1 alleles and the susceptibility of Iranian patients with breast cancer.

作者信息

Ghaderi A, Talei A, Gharesi-Fard B, Farjadian S H, Amirzargar A, Vasei M

机构信息

Medical School, Shiraz University of Medical Sciences, Department of Immunology, Shiraz, Iran.

出版信息

Pathol Oncol Res. 2001;7(1):39-41. doi: 10.1007/BF03032603.

DOI:10.1007/BF03032603

PMID:11349219

Abstract

Breast cancer is considered a major malignancy among women worldwide. The contribution of genetic elements to the onset of familial breast cancer has already been established. The current study investigate the alfele frequency of HLA-DRB 1 in 36 primary operable female breast cancer patients from southern Iran by polymerase chain reaction using sequence specific primers (PCR-SSP). Results were compared with those of 36 female control subjects. Statistical analysis was performed and P values were determined for each character. Our results indicated that the frequency of HLA-DRB 112 allele is significantly higher in the patient group (p<0.03) compared to the control group. In addition, HLA-DRB111 appeared to be as the most frequent allele in the control group (29.2%) and had approximately the same distribution among the patient group (22.5%).

摘要

乳腺癌被认为是全球女性中的一种主要恶性肿瘤。遗传因素对家族性乳腺癌发病的作用已得到证实。本研究采用序列特异性引物聚合酶链反应（PCR-SSP），调查了伊朗南部36例原发性可手术女性乳腺癌患者中HLA-DRB 1的等位基因频率。将结果与36名女性对照受试者的结果进行比较。进行了统计分析，并确定了每个特征的P值。我们的结果表明，与对照组相比，患者组中HLA-DRB 112等位基因的频率显著更高（p<0.03）。此外，HLA-DRB111似乎是对照组中最常见的等位基因（29.2%），在患者组中的分布大致相同（22.5%）。