HLA II类基因多态性：突尼斯乳腺癌的保护因素还是风险因素？
HLA class II polymorphism: protective or risk factors to breast cancer in Tunisia?
作者信息
Baccar Harrath Amal, Yacoubi Loueslati Besma, Troudi Wafa, Hmida Slama, Sedkaoui Syrine, Dridi Amel, Jridi Afef, Ben Ayed Farhat, Ben Rhomdhane Khaled, Ben Ammar Elgaaied Amel
机构信息
Laboratory of Molecular Genetics, Immunology and Biotechnology, Faculty of Sciences of Tunis, ElManar University, Tunis, 1060, Tunisia.
出版信息
Pathol Oncol Res. 2006;12(2):79-81. doi: 10.1007/BF02893448. Epub 2006 Jun 24.
HLA system plays a key role in the tumor cells' escape from immune surveillance. Herein is the first report on the correlation of the susceptibility to breast cancer with HLA class II markers in Tunisia. Molecular typing of HLA-DRB1 and -DQB1 loci was undertaken for 70 Tunisian female patients. Comparison of allele and haplotype distribution between patients and 70 female control subjects reveals a negative association between HLADRB1* 07-DQB1*02 and the incidence of breast cancer in the Tunisian population.
人类白细胞抗原（HLA）系统在肿瘤细胞逃避免疫监视过程中起着关键作用。本文首次报道了突尼斯人群中HLAⅡ类分子标记与乳腺癌易感性之间的相关性。对70例突尼斯女性患者进行了HLA-DRB1和-DQB1基因座的分子分型。通过比较患者与70名女性对照受试者之间的等位基因和单倍型分布，发现HLADRB1* 07-DQB1*02与突尼斯人群乳腺癌发病率呈负相关。
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