阔叶榕甲醇提取物对胃肠道活性的评估。

Evaluation of methanolic extract of Ficus platyphylla on gastrointestinal activity.

作者信息

Amos S, Binda L, Chindo B, Akah P, Abdurahman M, Danmallam H U, Wambebe C, Gamaniel K

机构信息

Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, P. M. B. 21, Abuja, Nigeria.

出版信息

Indian J Exp Biol. 2001 Jan;39(1):63-7.

PMID:11349528

Abstract

Methanolic extract of Ficus platyphylla was tested on isolated rabbit jejunum, rat duodenum and gastrointestinal motility in mice. The extract showed a biphasic effect on isolated smooth muscle. Lower concentration of extract caused contraction, while higher concentrations produced relaxation. The contractile phase was attenuated by atropine, while relaxant phase attenuated histamine induced contraction of guinea pig ileum. The extract also exhibited a dose-dependent inhibition of gastrointestinal motility. Acute toxicity test in mice established LD50 value (i.p.) of the extract to be 2000 mg/kg. Preliminary phytochemical screening of the extract gave positive test for flavonoids, tannins and saponins.

摘要

对宽叶榕的甲醇提取物进行了离体兔空肠、大鼠十二指肠及小鼠胃肠动力试验。该提取物对离体平滑肌呈现双相作用。较低浓度的提取物引起收缩，而较高浓度则产生舒张作用。收缩相可被阿托品减弱，而舒张相可减弱组胺诱导的豚鼠回肠收缩。该提取物还表现出对胃肠动力的剂量依赖性抑制作用。小鼠急性毒性试验确定该提取物的半数致死量（腹腔注射）为2000 mg/kg。对该提取物进行的初步植物化学筛选显示黄酮类、单宁和皂苷呈阳性反应。