无花果（桑科）茎皮水提取物的植物化学筛选及其对实验动物肌肉活动的影响。

Phytochemical screening and effect of aqueous extract of Ficus sycomorus L. (Moraceae) stembark on muscular activity in laboratory animals.

作者信息

Sandabe U K, Onyeyili P A, Chibuzo G A

机构信息

Department of Veterinary Physiology and Pharmacology, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria.

出版信息

J Ethnopharmacol. 2006 Feb 20;103(3):481-3. doi: 10.1016/j.jep.2005.08.025. Epub 2005 Oct 21.

DOI:10.1016/j.jep.2005.08.025

PMID:16243463

Abstract

The stembark of Ficus sycomorus was collected, dried and extracted, to screen for some chemical constituents and study its effect on muscle contraction. The duodena and recti abdominis of 10 guinea pigs weighing between 330 and 345 g and 10 frogs weighing between 180 and 201 g, respectively, were isolated and used for this study. The extract was tested to see its effect on acetylcholine (ACH) induced contraction on kymograph. The extract reduced the acetylcholine contractile responses of guinea pigs duodena and recti abdominis muscles of frogs significantly, thus showing inhibitory effect on muscle contraction. The extract showed the presence of gallic tannins, saponins, reducing sugars, alkaloids and flavone aglycones. It was concluded that the extract has inhibitory effect on both smooth and skeletal muscles contractions and contains important constituents for pharmacological activities.

摘要

收集了埃及榕的茎皮，进行干燥和提取，以筛选一些化学成分并研究其对肌肉收缩的影响。分别选用10只体重在330至345克之间的豚鼠和10只体重在180至201克之间的青蛙，分离出它们的十二指肠和腹直肌用于本研究。将提取物在记纹鼓上测试其对乙酰胆碱（ACH）诱导收缩的影响。该提取物显著降低了豚鼠十二指肠和青蛙腹直肌对乙酰胆碱的收缩反应，从而显示出对肌肉收缩的抑制作用。提取物中含有没食子单宁、皂苷、还原糖、生物碱和黄酮苷元。得出的结论是，该提取物对平滑肌和骨骼肌的收缩均有抑制作用，并且含有具有药理活性的重要成分。