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英格兰和威尔士老年人自我报告的药物使用情况。

Self-reported medication use for older people in England and Wales.

作者信息

Chen Y F, Dewey M E, Avery A J

机构信息

Trent Institute for Health Services Research, UK.

出版信息

J Clin Pharm Ther. 2001 Apr;26(2):129-40. doi: 10.1046/j.1365-2710.2001.00333.x.

Abstract

OBJECTIVES

To describe the patterns of self-reported medication use, including both prescription and non-prescription drugs, for older people in five areas in England and Wales, and to identify the effects of socio-demographic features on medication use.

DESIGN

A cross-sectional survey on population random samples of people aged 65 and over. The survey is a part of the screening interviews at the first stage of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) carried out between 1991 and 1994. The sample was stratified to provide equal numbers in the 65-74 years and 75 years and over age groups.

SETTING

Three urban (Newcastle, Nottingham and Oxford) and two rural (Cambridgeshire and Gwynedd) centres. Older people living in both the general community and institutions were included.

PARTICIPANTS

12489 older people whose medication data were collected among the 13009 participants of the CFAS, of which the participation rate is 80%.

RESULTS

Overall prevalence of medication use was 75% (95% confidence interval 74-76%) for people aged 65-74 and 84% (83-85%) for people aged 75 and over, with a mean number of 2.03 (standard deviation 1.95) and 2.47 (2.02) drugs reported per respondent in each group, respectively. Concurrent use of five or more drugs (polypharmacy) was found in 11% (10-12%) of people in the 65-74 age group and in 15% (14-16%) in the 75 and over age group. People aged 75 and over were more likely to be taking at least one drug than people aged 65-74 (OR=1.69, 1.54-1.85), and women were more likely to be so compared with men (OR=1.43, 1.30-1.56). Centre variation was found but none of the centres consistently showed higher or lower usage of medications across the major drug categories. People living in institutions were more likely to be taking gastrointestinal drugs, central nervous system drugs and experience polypharmacy. The use of respiratory and central nervous system drugs (except hypnotics and anxiolytics) increased in lower social class and decreased in people attending full-time education for 10 years or more. The use of haematology/dietetic drugs (85% of which were vitamin and mineral preparations) decreased in lower social class.

CONCLUSION

This study provides representative estimates of medication usage among older people in England and Wales and identified associated factors and regional variations for medication use in a category-specific manner. The findings, suggesting the existence of centre variation and the association between type of accommodation, social class and medication use warrant further investigation.

摘要

目的

描述英格兰和威尔士五个地区老年人自我报告的药物使用模式,包括处方药和非处方药,并确定社会人口学特征对药物使用的影响。

设计

对65岁及以上人群的人口随机样本进行横断面调查。该调查是1991年至1994年进行的医学研究委员会认知功能与衰老研究(MRC CFAS)第一阶段筛查访谈的一部分。样本进行了分层,以便在65 - 74岁和75岁及以上年龄组中提供相等数量的样本。

地点

三个城市中心(纽卡斯尔、诺丁汉和牛津)和两个农村中心(剑桥郡和圭内斯)。纳入了居住在普通社区和机构中的老年人。

参与者

在CFAS的13009名参与者中收集了12489名老年人的用药数据,参与率为80%。

结果

65 - 74岁人群的总体药物使用率为75%(95%置信区间74 - 76%),75岁及以上人群为84%(83 - 85%),每组中每位受访者报告的药物平均数量分别为2.03(标准差1.95)和2.47(2.02)。65 - 74岁年龄组中11%(10 - 12%)的人同时使用五种或更多药物(多重用药),75岁及以上年龄组中为15%(14 - 16%)。75岁及以上的人比65 - 74岁的人更有可能服用至少一种药物(比值比=1.69,1.54 - 1.85),女性比男性更有可能如此(比值比=1.43,1.30 - 1.56)。发现了中心差异,但没有一个中心在主要药物类别中始终显示出较高或较低的药物使用率。居住在机构中的人更有可能服用胃肠道药物、中枢神经系统药物并经历多重用药。社会阶层较低者呼吸和中枢神经系统药物(催眠药和抗焦虑药除外)的使用增加,接受全日制教育10年或更长时间的人使用减少。社会阶层较低者血液学/营养药物(其中85%为维生素和矿物质制剂)的使用减少。

结论

本研究提供了英格兰和威尔士老年人药物使用情况的代表性估计,并按类别确定了药物使用的相关因素和地区差异。研究结果表明存在中心差异以及居住类型、社会阶层与药物使用之间的关联,值得进一步调查。

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