Linjakumpu Tarja, Hartikainen Sirpa, Klaukka Timo, Veijola Juha, Kivelä Sirkka-Liisa, Isoaho Raimo
University of Oulu, Department of Psychiatry, P.O. Box 5000, Peltolantie 5, Finland.
J Clin Epidemiol. 2002 Aug;55(8):809-17. doi: 10.1016/s0895-4356(02)00411-0.
To assess changes in medicine use and polypharmacy, two cross-sectional surveys were carried out among community-dwelling persons aged 64 years or over in 1990-91 (n = 1,131) and 1998-99 (n = 1,197) in the municipality of Lieto in southwestern Finland. In addition to drug use, the questionnaire included items on social background, quality of life, and home nursing services. Among those surveyed, 78% in 1990-1991 and 88% in 1998-1999 (P =.001) used prescription drugs during 7 days prior to the interview. The most commonly used medications were for the cardiovascular and central nervous systems. The number of medications per person increased from 3.1 (SD 2.8) to 3.8 (SD 3.1) (P =.0001), and polypharmacy (concominant use of over five medications) increased from 19 to 25% (P =.006). These changes were most prominent among persons aged 85 years or over, especially among women. Polypharmacy is a complex and worrying phenomenon that merits more research.
为评估药物使用和多重用药情况的变化，1990 - 1991年（n = 1131）和1998 - 1999年（n = 1197）在芬兰西南部列托市对64岁及以上的社区居民进行了两项横断面调查。除药物使用情况外，问卷还包括社会背景、生活质量和家庭护理服务等项目。在接受调查者中，1990 - 1991年有78%，1998 - 1999年有88%（P = 0.001）在访谈前7天内使用过处方药。最常用的药物是用于心血管和中枢神经系统的药物。人均用药数量从3.1（标准差2.8）增加到3.8（标准差3.1）（P = 0.0001），多重用药（同时使用超过五种药物）从19%增加到25%（P = 0.006）。这些变化在85岁及以上人群中最为显著，尤其是女性。多重用药是一个复杂且令人担忧的现象，值得更多研究。
