Edgley S A
Department of Anatomy, Downing Street, Cambridge CB2 3DY, UK.
J Physiol. 2001 May 15;533(Pt 1):51-6. doi: 10.1111/j.1469-7793.2001.0051b.x.
In order to use electrical stimulation or biological repair to attempt to alleviate spinal cord dysfunction, a key problem will be how to target the intervention. Since the majority of inputs to spinal motoneurones originate from intrinsic spinal premotor interneurones, these are key targets for interventions that may help restore function. Information on the organisation of these neurones could thus be crucially important to determine how to proceed. Understanding the organisation of spinal interneurones is no easy task. In this article I review evidence of the connectivity of some of the groups of spinal premotor interneurones that have been studied, focusing particularly on whether they form subgroups and how these can be identified.
为了利用电刺激或生物修复来尝试缓解脊髓功能障碍，一个关键问题将是如何确定干预靶点。由于脊髓运动神经元的大多数输入源自脊髓内源性运动前中间神经元，因此这些神经元是可能有助于恢复功能的干预措施的关键靶点。因此，关于这些神经元组织的信息对于确定如何开展研究可能至关重要。了解脊髓中间神经元的组织并非易事。在本文中，我回顾了一些已被研究的脊髓运动前中间神经元组群的连接性证据，特别关注它们是否形成亚组以及如何识别这些亚组。
