在1型和2型糖尿病患者中使用自行配制的赖脯胰岛素和精蛋白锌赖脯胰岛素混悬液混合物改善血糖控制。

Improved glycaemic control with the use of self-prepared mixtures of insulin lispro and insulin lispro protamine suspension in patients with types 1 and 2 diabetes.

作者信息

Roach P, Strack T, Arora V, Zhao Z

机构信息

Lilly Research Laboratories, Eli Lilly and Company, DC2042, Indianapolis, IN 46285, USA.

出版信息

Int J Clin Pract. 2001 Apr;55(3):177-82.

PMID:11351771

Abstract

A total of 166 patients (102 type 1, 64 type 2) were randomised to insulin lispro (LP) combined with insulin lispro protamine suspension (NPL), an intermediate-acting formulation of LP, or to regular human insulin (HR) combined with human NPH insulin (NPH) in this open-label, parallel study. Insulin doses were similar at endpoint. Blood glucose (BG) measurements (before and two hours after meals, bedtime, 3 a.m.)(mmol/l) were lower with LP/NPL two hours after breakfast (8.84 +/- 0.32 vs 10.29 +/- 0.41, p < 0.001), before lunch (6.21 +/- 0.20 vs 7.10 +/- 0.31, p = 0.016), two hours after the evening meal (10.18 +/- 0.36 vs 7.86 +/- 0.28, p < 0.0.001), and at bedtime (7.85 +/- 0.28 vs 9.43 +/- 0.40, p = 001). HbA1c was lower for LP/NPL at endpoint (7.54 +/- 0.11% vs 7.92 +/- 0.10%, p = 0.019). There was no difference in hypoglycaemia or insulin antibody levels. LP/NPL resulted in better glycaemic control than HR/NPH without increasing the risk of hypoglycaemia.

摘要

在这项开放标签的平行研究中，共有166例患者（102例1型，64例2型）被随机分为赖脯胰岛素（LP）联合赖脯胰岛素鱼精蛋白混悬液（NPL，LP的中效制剂）组，或常规人胰岛素（HR）联合人低精蛋白胰岛素（NPH）组。终点时胰岛素剂量相似。早餐后两小时（8.84±0.32 vs 10.29±0.41，p<0.001）、午餐前（6.21±0.20 vs 7.10±0.31，p = 0.016）、晚餐后两小时（10.18±0.36 vs 7.86±0.28，p<0.001）及睡前（7.85±0.28 vs 9.43±0.40，p = 0.01）时，LP/NPL组的血糖（BG）测量值（餐前及餐后两小时、睡前、凌晨3点）（mmol/l）较低。终点时LP/NPL组的糖化血红蛋白（HbA1c）较低（7.54±0.11% vs 7.92±0.10%，p = 0.019）。低血糖或胰岛素抗体水平无差异。LP/NPL在不增加低血糖风险的情况下，血糖控制优于HR/NPH。