pH响应性聚合物微球：在细胞内pH范围内快速释放包封物质本研究得到了美国国家科学基金会（授予麻省理工学院生物技术过程工程中心的合作协议号ECC9843342）、美国国立卫生研究院（GM26698）以及美国陆军部（授予创新微创治疗中心的合作协议DAMD 17 - 99 - 2 - 9 - 001）的资助。D.M.L.感谢美国国立卫生研究院提供博士后奖学金（NRSA奖学金号1 F32 GM20227 - 01）。扫描电子显微镜和共聚焦显微镜图像由东北大学电子显微镜中心的威廉·福尔采集。感谢大卫·普特南博士、大卫·廷和汤米·托马斯进行的有益讨论。 - Suppr

Suppr

超能文献

pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH Financial support was provided by the NSF (Cooperative Agreement No. ECC9843342 to the MIT Biotechnology Process Engineering Center), the NIH (GM26698), and the Department of the Army (Cooperative Agreement DAMD 17-99-2-9-001 to the Center for Innovative Minimally Invasive Therapy). D.M.L. wishes to thank the NIH for a Postdoctoral Fellowship (NRSA Fellowship No. 1 F32 GM20227-01). Scanning electron microscopy and confocal microscopy images were acquired by William Fowle at the Northeastern University Center for Electron Microscopy. Dr. David Putnam, David Ting, and Tommy Thomas are thanked for helpful discussions.

作者信息

Lynn David M., Amiji Mansoor M., Langer Robert

机构信息

Department of Chemical Engineering, Room E25-342 Massachusetts Institute of Technology Cambridge, MA 02139 (USA).

出版信息

Angew Chem Int Ed Engl. 2001 May 4;40(9):1707-1710.

PMID:11353487

Abstract

摘要

相似文献

pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH Financial support was provided by the NSF (Cooperative Agreement No. ECC9843342 to the MIT Biotechnology Process Engineering Center), the NIH (GM26698), and the Department of the Army (Cooperative Agreement DAMD 17-99-2-9-001 to the Center for Innovative Minimally Invasive Therapy). D.M.L. wishes to thank the NIH for a Postdoctoral Fellowship (NRSA Fellowship No. 1 F32 GM20227-01). Scanning electron microscopy and confocal microscopy images were acquired by William Fowle at the Northeastern University Center for Electron Microscopy. Dr. David Putnam, David Ting, and Tommy Thomas are thanked for helpful discussions.

Angew Chem Int Ed Engl. 2001 May 4;40(9):1707-1710.

The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2 Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, a NIH Postdoctoral Fellowship to C.S.B., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr George T. Furst, Dr. Patrick J. Carroll, and Dr. Rakesh Kohli of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra, respectively.

Angew Chem Int Ed Engl. 2001 Jan 5;40(1):196-199.

The Spongistatins: Architecturally Complex Natural Products-Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, NIH Postdoctoral Fellowships to A.M.B. and W.H.M., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr. George T. Furst, Dr. Patrick J. Carroll, Dr. Rakesh Kohli, and Mr John Dykins of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra.

Angew Chem Int Ed Engl. 2001 Jan 5;40(1):191-195.

The Synthesis of CP-263,114 and CP-225,917: Striking Long-Range Stereocontrol in the Fashioning of C7 Financial support was provided by the National Institutes of Health (Grant nos. CA-28824 and HL-25848 for S.J.D., CA-08748 for the Sloan-Kettering Institute Core Facility). Q.T. gratefully acknowledges the US Department of Defense for a postdoctoral fellowship (U.S. Army grant no. DAMD-17-99-1-9373). We thank the Pfizer Corporation, particularly Dr. T. Kaneko and Dr. T. T. Dabrah for discussions and for providing valuable CP samples from fermentation broth. We are grateful to Dr. Dongfang Meng for his major contributions to this work. We also thank George Sukenick of the Sloan-Kettering Institute Core Facility for mass spectral analyses and assistance in NMR spectroscopic and HPLC analyses, and Sylvi Rusli for mass spectral analyses.

Angew Chem Int Ed Engl. 2000 Dec 15;39(24):4509-4511.

Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for generous support, and Dr. Anne Butlin (AZ) and Dr. Nick Bampos (Cambridge) for valuable assistance.

Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4055-4060.

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Angew Chem Int Ed Engl. 2001 Jan 5;40(1):202-206.

Visualization of Single Multivalent Receptor-Ligand Complexes by Transmission Electron Microscopy The authors thank Colleen Lavin (UW Madison, Microscopy Resource) and Kim Dickson for experimental support. This work was supported in part by the NIH (GM 55984). J.E.G. acknowledges the NIH Biotechnology Training Grant for support (T32GM08349). L.E.S. was supported by an NIH predoctoral fellowship (GM 18750).

Angew Chem Int Ed Engl. 2000 Dec 15;39(24):4567-4570.

"Cap-Tag"-Novel Methods for the Rapid Purification of Oligosaccharides Prepared by Automated Solid-Phase Synthesis Financial support from the donors of the Petroleum Research Fund, administered by the ACS (ACS-PRF 34649-G1), Merck (Predoctoral Fellowship for E.R.P.), Boehringer-Ingelheim (Predoctoral Fellowship for E.R.P.), and the NIH (Biotechnology Training Grant for M.C.H.) is gratefully acknowledged. Funding for the MIT-DCIF Inova 501 was provided by the NSF (Award CHE-9808061). Funding for the MIT-DCIF Avance (DPX) 400 was provided by the NIH (Award 1S10RR13886-01). We thank Silicycle (Quebec City, Canada) for the generous gift of fluorous silica gel and isocyanate silica gel scavenger resin. We thank Dr. O. Plante for helpful discussions and help with the automated oligosaccharide synthesizer.

Angew Chem Int Ed Engl. 2001 Dec 3;40(23):4433-4437. doi: 10.1002/1521-3773(20011203)40:23<4433::aid-anie4433>3.0.co;2-8.

Resolution and Kinetic Stability of a Chiral Supramolecular Assembly Made of Labile Components Coordination Number Incommensurate Cluster Formation, Part 18. Financial support of this work was provided by NSF CHE-9709621 and by NSF and NATO-NSF exchange grants INT-9603212 and SRG 951516, respectively. We thank the Alexander-von-Humboldt Foundation for a Fellowship to A.T., and a Humboldt Research Award for Senior U.S. Scientists to K.R., and the Miller Foundation for a fellowship to M.Z. The authors gratefully acknowledge the assistance of Dr. F. J. Hollander and Dr. D. L. Caulder in selecting and mounting a suitable single crystal, and Prof. Julie A. Leary, Dr. Ulla N. Andersen, and J. J. Miranda for measuring mass spectra. Part 17: M. Ziegler, J. J. Miranda, U. N. Andersen, D. W. Johnson, J. A. Leary, K. N. Raymond, Angew. Chem., in press.

Angew Chem Int Ed Engl. 2001 Jan 5;40(1):157-160.

Combinatorial Libraries of Metal-Ligand Assemblies with an Encapsulated Guest Molecule Coordination Number Incommensurate Cluster Formation, Part 17. Financial support of this work was provided by NSF CHE-9709621 and a NATO-NSF exchange grant SRG 951516. We thank the Miller Foundation for a fellowship to M.Z. Part 16: R. M. Yeh, M. Ziegler, D. W. Johnson, A. J. Terpin, K. N. Raymond, Inorg. Chem. 2001, in press.

Angew Chem Int Ed Engl. 2001 Feb 16;40(4):733-736.

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