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Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for generous support, and Dr. Anne Butlin (AZ) and Dr. Nick Bampos (Cambridge) for valuable assistance.

作者信息

Paterson Ian, Chen David Y.-K., Coster Mark J., Aceña Jose L., Bach Jordi, Gibson Karl R., Keown Linda E., Oballa Renata M., Trieselmann Thomas, Wallace Debra J., Hodgson Andrew P., Norcross Roger D.

机构信息

University Chemical Laboratory Lensfield Road, Cambridge, CB2 1EW (UK).

出版信息

Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4055-4060.

PMID:12404491
Abstract
摘要

相似文献

1
Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for generous support, and Dr. Anne Butlin (AZ) and Dr. Nick Bampos (Cambridge) for valuable assistance.（+）-Altohyrtin A/海绵抑素1的立体控制全合成 本研究得到了英国工程与自然科学研究委员会（GR/L41646）、剑桥联邦信托基金（授予M.J.C.的奖学金）、欧盟（授予J.L.A.的玛丽·居里博士后奖学金）、德国研究基金会（授予T.T.的博士后奖学金）、加拿大自然科学与工程研究理事会（授予R.M.O.的博士后奖学金）、丘吉尔学院（授予D.J.W.的研究奖学金）、国王学院和剑桥西姆斯基金（授予D.Y.K.C.的奖学金）的资金支持。我们还要感谢默克公司和阿斯利康制药公司的慷慨支持，以及安妮·巴特林博士（阿斯利康）和尼克·班波斯博士（剑桥）提供的宝贵帮助。
Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4055-4060.
2
Catalytic Asymmetric Synthesis of Epoxides from Aldehydes Using Sulfur Ylides with In Situ Generation of Diazocompounds We thank the EPSRC (K.M.L., M.J.P., J.R.S.), Avecia for the support of a studentship (M.P.), the EU for a Marie Curie Fellowship (E.A.; HPMF-CT-1999-00076), and Sheffield University for financial support. We thank Dr. J. Blacker (Avecia), Dr. R. V. H. Jones (Zeneca Agrochemicals), and Dr. R. Fieldhouse (Zeneca Agrochemicals) for their interest in this work.使用重氮化合物原位生成的硫叶立德由醛催化不对称合成环氧化物 我们感谢英国工程与物理科学研究委员会（K.M.L.、M.J.P.、J.R.S.）、Avecia公司提供的奖学金支持（M.P.）、欧盟提供的玛丽·居里奖学金（E.A.；HPMF-CT-1999-00076）以及谢菲尔德大学的资金支持。我们感谢J. Blacker博士（Avecia公司）、R. V. H. Jones博士（捷利康农用化学品公司）和R. Fieldhouse博士（捷利康农用化学品公司）对本研究的关注。
Angew Chem Int Ed Engl. 2001 Apr 17;40(8):1430-1433.
3
The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2 Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, a NIH Postdoctoral Fellowship to C.S.B., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr George T. Furst, Dr. Patrick J. Carroll, and Dr. Rakesh Kohli of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra, respectively.海绵他汀类化合物：结构复杂的天然产物——第二部分：C(29 - 51)亚基的合成、片段组装以及(+)-海绵他汀2的最终合成 本研究得到了美国国立卫生研究院（国立癌症研究所）的资助，资助编号为CA - 70329；还给C.S.B.提供了美国国立卫生研究院博士后奖学金，给N.M.提供了日本学术振兴会奖学金，给V.A.D.提供了英国皇家学会富布赖特奖学金。我们还感谢第一制药株式会社和田边制药株式会社提供的资金支持。最后，我们感谢宾夕法尼亚大学光谱服务中心的George T. Furst博士、Patrick J. Carroll博士和Rakesh Kohli博士，他们分别在获取和解释高场核磁共振谱、X射线晶体结构以及质谱方面提供了帮助。
Angew Chem Int Ed Engl. 2001 Jan 5;40(1):196-199.
4
The Spongistatins: Architecturally Complex Natural Products-Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, NIH Postdoctoral Fellowships to A.M.B. and W.H.M., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr. George T. Furst, Dr. Patrick J. Carroll, Dr. Rakesh Kohli, and Mr John Dykins of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra.海绵他汀类化合物：结构复杂的天然产物——第一部分：通过构建高级ABCD片段对（+）-海绵他汀1进行形式合成 美国国立卫生研究院（国家癌症研究所）通过CA-70329号资助提供了资金支持，美国国立卫生研究院向A.M.B.和W.H.M.提供了博士后奖学金，日本学术振兴会向N.M.提供了奖学金，英国皇家学会富布赖特奖学金向V.A.D.提供了奖学金。我们还感谢第一制药株式会社和田边制药株式会社的资金支持。最后，我们感谢宾夕法尼亚大学光谱服务中心的George T. Furst博士、Patrick J. Carroll博士、Rakesh Kohli博士和John Dykins先生在获取和解释高场核磁共振光谱、X射线晶体结构和质谱方面提供的帮助。
Angew Chem Int Ed Engl. 2001 Jan 5;40(1):191-195.
5
Solvent-Free, Low-Temperature, Selective Hydrogenation of Polyenes using a Bimetallic Nanoparticle Ru-Sn Catalyst We thank Dr. R. G. Bell for assistance with the computer graphics, Drs. P. A. Midgeley, V. Keast, and M. Weyland for help with STEM, and gratefully acknowledge the support (via a rolling grant to J.M.T. and an award to B.F.G.J.) of EPSRC and the award of a research fellowship (for G.S.) from the Leverhulme Foundation and a Marie Curie Fellowship within the TMR Programme of the European Commission (for S.H.).使用双金属纳米颗粒Ru-Sn催化剂对多烯进行无溶剂、低温选择性氢化 我们感谢R.G. Bell博士在计算机图形方面提供的帮助，感谢P.A. Midgeley博士、V. Keast博士和M. Weyland博士在扫描透射电子显微镜方面提供的帮助，并衷心感谢工程和物理科学研究委员会的支持（通过向J.M.T.提供的滚动资助以及向B.F.G.J.颁发的奖项），以及Leverhulme基金会授予的研究奖学金（给G.S.）和欧盟委员会TMR计划内的玛丽·居里奖学金（给S.H.）。
Angew Chem Int Ed Engl. 2001 Apr 1;40(7):1211-1215.
6
Total Synthesis of Apoptolidin: Part 2. Coupling of Key Building Blocks and Completion of the Synthesis We thank Dr. C. Khosla and Dr. Y. Hayakawa for generous gifts of apoptolidin, and Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, American Biosciences, a predoctoral fellowship from Boehringer Ingelheim (to Y.L.), a postdoctoral fellowship the George Hewitt Foundation (to K.C.F.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough.
Angew Chem Int Ed Engl. 2001 Oct 15;40(20):3854-3857.
7
Application of Chiral Sulfides to Catalytic Asymmetric Aziridination and Cyclopropanation with In Situ Generation of the Diazo Compound We thank Avecia (M.P.), the EPSRC (M.F.), the EU for a Marie Curie Fellowship (E.A.; HPMF-CT-1999-00076), Lu'an Teacher's College and the Education Minister of The Peoples Republic of China (G.F.), and Sheffield University for financial support. We thank Dr. J. Blacker (Avecia), Dr. R. V. H. Jones (Zeneca Agrochemicals), and Dr. R. Fieldhouse (Zeneca Agrochemicals) for their interest and support of this work.手性硫化物在催化不对称氮杂环丙烷化反应和环丙烷化反应中的应用：重氮化合物的原位生成 我们感谢Avecia公司（M.P.）、英国工程和物理科学研究委员会（M.F.）、欧盟提供的玛丽·居里奖学金（E.A.；HPMF-CT-1999-00076）、六安师范学院和中华人民共和国教育部（G.F.）以及谢菲尔德大学的资金支持。我们感谢J. Blacker博士（Avecia公司）、R. V. H. Jones博士（捷利康农用化学品公司）和R. Fieldhouse博士（捷利康农用化学品公司）对本工作的关注和支持。
Angew Chem Int Ed Engl. 2001 Apr 17;40(8):1433-1436.
8
Butane-2,3-Diacetal-Desymmetrized Glycolic Acid-A New Building Block for the Stereoselective Synthesis of Enantiopure alpha-Hydroxy Acids We thank the EU (Marie Curie Fellowship to E.D.), the EPSRC (to D.J.D.), the Novartis Research Fellowship (to S.V.L.), and Pfizer Gobal Research and Development, Groton, USA, for financial support.
Angew Chem Int Ed Engl. 2001 Aug 3;40(15):2906-2909.
9
Resolution and Kinetic Stability of a Chiral Supramolecular Assembly Made of Labile Components Coordination Number Incommensurate Cluster Formation, Part 18. Financial support of this work was provided by NSF CHE-9709621 and by NSF and NATO-NSF exchange grants INT-9603212 and SRG 951516, respectively. We thank the Alexander-von-Humboldt Foundation for a Fellowship to A.T., and a Humboldt Research Award for Senior U.S. Scientists to K.R., and the Miller Foundation for a fellowship to M.Z. The authors gratefully acknowledge the assistance of Dr. F. J. Hollander and Dr. D. L. Caulder in selecting and mounting a suitable single crystal, and Prof. Julie A. Leary, Dr. Ulla N. Andersen, and J. J. Miranda for measuring mass spectra. Part 17: M. Ziegler, J. J. Miranda, U. N. Andersen, D. W. Johnson, J. A. Leary, K. N. Raymond, Angew. Chem., in press.由不稳定组分构成的手性超分子组装体的分辨率和动力学稳定性：配位数不匹配的簇形成，第18部分。本研究得到了美国国家科学基金会（NSF）CHE - 9709621项目以及NSF和北约 - NSF交流基金INT - 9603212和SRG 951516的资助。我们感谢亚历山大·冯·洪堡基金会授予A.T.的奖学金、授予K.R.的洪堡资深美国科学家研究奖，以及米勒基金会授予M.Z.的奖学金。作者们衷心感谢F. J. 霍兰德博士和D. L. 考尔德博士在挑选和安装合适单晶方面提供的帮助，以及朱莉·A. 利里教授、乌拉·N. 安德森博士和J. J. 米兰达在测量质谱方面提供的帮助。第17部分：M. 齐格勒、J. J. 米兰达、U. N. 安德森、D. W. 约翰逊、J. A. 利里、K. N. 雷蒙德，《德国应用化学》，即将发表。
Angew Chem Int Ed Engl. 2001 Jan 5;40(1):157-160.
10
Total Synthesis of the Callipeltoside Aglycon We thank the EPSRC (R.D.M.D; GR/N08520), Girton College, Cambridge (R.M.), and Merck for support, and Setu P. Roday (Cambridge) for kindly assisting with the molecular modeling studies.Callipeltoside苷元的全合成 我们感谢英国工程与自然科学研究委员会（R.D.M.D；GR/N08520）、剑桥大学格顿学院（R.M.）和默克公司的支持，以及Setu P. Roday（剑桥）协助进行分子建模研究。
Angew Chem Int Ed Engl. 2001 Feb 2;40(3):603-607.

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