Gagliardi Agnese, Giuliano Elena, Venkateswararao Eeda, Fresta Massimo, Bulotta Stefania, Awasthi Vibhudutta, Cosco Donato
Department of Health Sciences, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
Department of Pharmaceutical Sciences, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Front Pharmacol. 2021 Feb 3;12:601626. doi: 10.3389/fphar.2021.601626. eCollection 2021.
Advances in nanotechnology have favored the development of novel colloidal formulations able to modulate the pharmacological and biopharmaceutical properties of drugs. The peculiar physico-chemical and technological properties of nanomaterial-based therapeutics have allowed for several successful applications in the treatment of cancer. The size, shape, charge and patterning of nanoscale therapeutic molecules are parameters that need to be investigated and modulated in order to promote and optimize cell and tissue interaction. In this review, the use of polymeric nanoparticles as drug delivery systems of anticancer compounds, their physico-chemical properties and their ability to be efficiently localized in specific tumor tissues have been described. The nanoencapsulation of antitumor active compounds in polymeric systems is a promising approach to improve the efficacy of various tumor treatments.
纳米技术的进步推动了新型胶体制剂的发展，这些制剂能够调节药物的药理和生物制药特性。基于纳米材料的疗法所具有的独特物理化学和技术特性，已在癌症治疗中实现了多项成功应用。纳米级治疗分子的大小、形状、电荷和图案是需要研究和调节的参数，以促进和优化细胞与组织的相互作用。在这篇综述中，已描述了将聚合物纳米颗粒用作抗癌化合物的药物递送系统、它们的物理化学性质以及它们有效定位于特定肿瘤组织的能力。将抗肿瘤活性化合物纳米封装于聚合物系统中，是提高各种肿瘤治疗疗效的一种有前景的方法。
