Arora A S, Conklin J L
Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Curr Gastroenterol Rep. 2001 Jun;3(3):191-9. doi: 10.1007/s11894-001-0021-8.
Dysphagia is a common symptom with which patients present. This review focuses primarily on the esophageal motor disorders that result in dysphagia. Following a brief description of the normal swallowing mechanisms and the messengers involved, more specific motor abnormalities are discussed. The importance of achalasia, as the only pathophysiologically defined esophageal motor disorder, is discussed in some detail, including recent developments in pathogenesis and treatment options. Other esophageal spastic disorders are described, with relevant manometric tracings included. In recent years, the importance of gastroesophageal reflux as a primary cause of esophageal dysmotility has been recognized, and this is also discussed. In addition, the motility disturbances that develop after surgical fundoplication are reviewed.
吞咽困难是患者常见的症状。本综述主要关注导致吞咽困难的食管运动障碍。在简要描述正常吞咽机制及相关介质后，将讨论更具体的运动异常。贲门失弛缓症作为唯一经病理生理学定义的食管运动障碍，其重要性将得到较为详细的讨论，包括发病机制和治疗选择的最新进展。还将描述其他食管痉挛性疾病，并附上相关测压描记图。近年来，胃食管反流作为食管动力障碍主要原因的重要性已得到认可，对此也将进行讨论。此外，还将回顾胃底折叠术后出现的动力障碍。
