Benabarre A, Vieta E, Colom F, Martínez-Arán A, Reinares M, Gastó C
Clinical Institute of Psychiatry and Psychology, Department of Psychiatry, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain.
Eur Psychiatry. 2001 Apr;16(3):167-72. doi: 10.1016/s0924-9338(01)00559-4.
The validity and nosologic status of schizoaffective disorder is still a controversial issue. This study was conducted to analyze the demographic, clinical and prognostic variables that determine the validity of the diagnosis of schizoaffective disorder bipolar type. We analyzed and compared 138 outpatients: 67 with type I bipolar disorder, 34 with schizoaffective disorder bipolar type and 37 with schizophrenia. They were all diagnosed following research diagnostic criteria and assessed according to the Schedule for Affective Disorders and Schizophrenia. Schizoaffective unipolar patients were excluded. The results reaffirmed that, from the standpoints of demographics, clinical features and prognosis, schizoaffective disorders bipolar type can be classified as a phenotypic form at an intermediate point between bipolar I disorder and schizophrenia. These results emphasize the importance of longitudinal follow-up in the diagnosis and assessment of psychotic syndromes. Although cross-sectional symptoms were closer to the schizophrenia spectrum, the course of the illness resembled more that of bipolar patients, resulting in an intermediate outcome.
分裂情感性障碍的有效性和疾病分类地位仍然是一个有争议的问题。本研究旨在分析决定双相型分裂情感性障碍诊断有效性的人口统计学、临床和预后变量。我们分析并比较了138名门诊患者：67名患有I型双相情感障碍，34名患有双相型分裂情感性障碍，37名患有精神分裂症。他们均按照研究诊断标准进行诊断，并根据情感障碍和精神分裂症日程表进行评估。排除了单相分裂情感性障碍患者。结果再次证实，从人口统计学、临床特征和预后的角度来看，双相型分裂情感性障碍可被归类为处于双相I型障碍和精神分裂症之间中间点的一种表型形式。这些结果强调了纵向随访在精神病综合征诊断和评估中的重要性。尽管横断面症状更接近精神分裂症谱系，但疾病进程更类似于双相情感障碍患者，导致了中间结果。
