铜绿假单胞菌中苯唑西林酶介导的对头孢吡肟耐药及对头孢他啶敏感
Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa.
作者信息
Aubert D, Poirel L, Chevalier J, Leotard S, Pages J M, Nordmann P
机构信息
Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France.
出版信息
Antimicrob Agents Chemother. 2001 Jun;45(6):1615-20. doi: 10.1128/AAC.45.6.1615-1620.2001.
Abstract
Pseudomonas aeruginosa clinical isolate SOF-1 was resistant to cefepime and susceptible to ceftazidime. This resistance phenotype was explained by the expression of OXA-31, which shared 98% amino acid identity with a class D beta-lactamase, OXA-1. The oxa-31 gene was located on a ca. 300-kb nonconjugative plasmid and on a class 1 integron. No additional efflux mechanism for cefepime was detected in P. aeruginosa SOF-1. Resistance to cefepime and susceptibility to ceftazidime in P. aeruginosa were conferred by OXA-1 as well.
摘要
铜绿假单胞菌临床分离株SOF-1对头孢吡肟耐药，对头孢他啶敏感。这种耐药表型可通过OXA-31的表达来解释，OXA-31与D类β-内酰胺酶OXA-1的氨基酸同一性为98%。oxa-31基因位于一个约300kb的非接合性质粒和一个1类整合子上。在铜绿假单胞菌SOF-1中未检测到针对头孢吡肟的其他外排机制。铜绿假单胞菌对头孢吡肟的耐药性和对头孢他啶的敏感性也由OXA-1介导。
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