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Integron-located oxa-32 gene cassette encoding an extended-spectrum variant of OXA-2 beta-lactamase from Pseudomonas aeruginosa.位于整合子的oxa - 32基因盒，其编码来自铜绿假单胞菌的OXA - 2β-内酰胺酶的超广谱变体。
Antimicrob Agents Chemother. 2002 Feb;46(2):566-9. doi: 10.1128/AAC.46.2.566-569.2002.
2
OXA-28, an extended-spectrum variant of OXA-10 beta-lactamase from Pseudomonas aeruginosa and its plasmid- and integron-located gene.OXA-28，一种源自铜绿假单胞菌的OXA-10β-内酰胺酶的超广谱变体及其位于质粒和整合子上的基因。
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OXA-15, an extended-spectrum variant of OXA-2 beta-lactamase, isolated from a Pseudomonas aeruginosa strain.OXA-15是一种从铜绿假单胞菌菌株中分离出的OXA-2β-内酰胺酶的超广谱变体。
Antimicrob Agents Chemother. 1997 Apr;41(4):785-90. doi: 10.1128/AAC.41.4.785.
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Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa.铜绿假单胞菌中苯唑西林酶介导的对头孢吡肟耐药及对头孢他啶敏感
Antimicrob Agents Chemother. 2001 Jun;45(6):1615-20. doi: 10.1128/AAC.45.6.1615-1620.2001.
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Antimicrob Agents Chemother. 1997 Oct;41(10):2188-95. doi: 10.1128/AAC.41.10.2188.
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OXA-46, a new class D beta-lactamase of narrow substrate specificity encoded by a blaVIM-1-containing integron from a Pseudomonas aeruginosa clinical isolate.OXA-46，一种新型D类β-内酰胺酶，底物特异性狭窄，由一株铜绿假单胞菌临床分离株中含blaVIM-1的整合子编码。
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Challenging Antimicrobial Susceptibility and Evolution of Resistance (OXA-681) during Treatment of a Long-Term Nosocomial Infection Caused by a Pseudomonas aeruginosa ST175 Clone.耐碳青霉烯类铜绿假单胞菌（OXA-681）在治疗长期医院感染中的抗药性及其演变
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An integron-associated beta-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum beta-lactamase IBC-1.来自铜绿假单胞菌的一种整合子相关β-内酰胺酶（IBC-2）是超广谱β-内酰胺酶IBC-1的一个变体。
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Antibiotics (Basel). 2014 Aug 21;3(3):398-434. doi: 10.3390/antibiotics3030398.
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Antibiotics as selectors and accelerators of diversity in the mechanisms of resistance: from the resistome to genetic plasticity in the β-lactamases world.抗生素作为耐药机制多样性的选择者和促进者：从耐药组学到β-内酰胺酶世界的遗传可塑性。
Front Microbiol. 2013 Feb 8;4:9. doi: 10.3389/fmicb.2013.00009. eCollection 2013.
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Strain-tailored double-disk synergy test detects extended-spectrum oxacillinases in Pseudomonas aeruginosa.应变定制双盘协同试验检测铜绿假单胞菌中的扩展谱苯唑西林酶。
J Clin Microbiol. 2011 Jun;49(6):2262-5. doi: 10.1128/JCM.02585-10. Epub 2011 Mar 30.
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OXA-163, an OXA-48-related class D β-lactamase with extended activity toward expanded-spectrum cephalosporins.OXA-163，一种与 OXA-48 相关的 D 类β-内酰胺酶，对扩展谱头孢菌素具有扩展的活性。
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Detection of the novel extended-spectrum beta-lactamase OXA-161 from a plasmid-located integron in Pseudomonas aeruginosa clinical isolates from Spain.从西班牙分离的铜绿假单胞菌临床株质粒定位的整合子中检测到新型超广谱β-内酰胺酶 OXA-161。
Antimicrob Agents Chemother. 2009 Dec;53(12):5288-90. doi: 10.1128/AAC.00822-09. Epub 2009 Sep 21.
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Diversity, epidemiology, and genetics of class D beta-lactamases.D 类β-内酰胺酶的多样性、流行病学和遗传学。
Antimicrob Agents Chemother. 2010 Jan;54(1):24-38. doi: 10.1128/AAC.01512-08. Epub 2009 Aug 31.

本文引用的文献

1
OXA-28, an extended-spectrum variant of OXA-10 beta-lactamase from Pseudomonas aeruginosa and its plasmid- and integron-located gene.OXA-28，一种源自铜绿假单胞菌的OXA-10β-内酰胺酶的超广谱变体及其位于质粒和整合子上的基因。
Antimicrob Agents Chemother. 2001 Feb;45(2):447-53. doi: 10.1128/AAC.45.2.447-453.2001.
2
OXA-24, a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain.OXA-24，一种在鲍曼不动杆菌临床菌株中具有碳青霉烯酶活性的新型D类β-内酰胺酶。
Antimicrob Agents Chemother. 2000 Jun;44(6):1556-61. doi: 10.1128/AAC.44.6.1556-1561.2000.
3
Class 1 integrons, gene cassettes, mobility, and epidemiology.1类整合子、基因盒、移动性与流行病学
Eur J Clin Microbiol Infect Dis. 1999 Nov;18(11):761-70. doi: 10.1007/s100960050398.
4
Sequence analysis of ARI-1, a novel OXA beta-lactamase, responsible for imipenem resistance in Acinetobacter baumannii 6B92.ARI-1的序列分析，ARI-1是一种新型OXAβ-内酰胺酶，与鲍曼不动杆菌6B92对亚胺培南耐药有关。
Antimicrob Agents Chemother. 2000 Jan;44(1):196-9. doi: 10.1128/AAC.44.1.196-199.2000.
5
OXA-type beta-lactamases.OXA型β-内酰胺酶
Curr Pharm Des. 1999 Nov;5(11):865-79.
6
Novel OXA-10-derived extended-spectrum beta-lactamases selected in vivo or in vitro.在体内或体外筛选出的新型源自OXA-10的超广谱β-内酰胺酶。
Antimicrob Agents Chemother. 1998 Dec;42(12):3113-6. doi: 10.1128/AAC.42.12.3113.
7
Extended-spectrum beta-lactamases in Pseudomonas aeruginosa.铜绿假单胞菌中的超广谱β-内酰胺酶
J Antimicrob Chemother. 1998 Aug;42(2):128-31. doi: 10.1093/jac/42.2.128.
8
Carbapenems as inhibitors of OXA-13, a novel, integron-encoded beta-lactamase in Pseudomonas aeruginosa.碳青霉烯类作为OXA-13的抑制剂，OXA-13是铜绿假单胞菌中一种新型的、整合子编码的β-内酰胺酶。
Microbiology (Reading). 1998 Apr;144 ( Pt 4):1021-1031. doi: 10.1099/00221287-144-4-1021.
9
OXA-18, a class D clavulanic acid-inhibited extended-spectrum beta-lactamase from Pseudomonas aeruginosa.OXA-18，一种来自铜绿假单胞菌的D类克拉维酸抑制型超广谱β-内酰胺酶。
Antimicrob Agents Chemother. 1997 Oct;41(10):2188-95. doi: 10.1128/AAC.41.10.2188.
10
OXA-15, an extended-spectrum variant of OXA-2 beta-lactamase, isolated from a Pseudomonas aeruginosa strain.OXA-15是一种从铜绿假单胞菌菌株中分离出的OXA-2β-内酰胺酶的超广谱变体。
Antimicrob Agents Chemother. 1997 Apr;41(4):785-90. doi: 10.1128/AAC.41.4.785.

位于整合子的oxa - 32基因盒，其编码来自铜绿假单胞菌的OXA - 2β-内酰胺酶的超广谱变体。

Integron-located oxa-32 gene cassette encoding an extended-spectrum variant of OXA-2 beta-lactamase from Pseudomonas aeruginosa.

作者信息

Poirel Laurent, Gerome Patrick, De Champs Christophe, Stephanazzi Jean, Naas Thierry, Nordmann Patrice

机构信息

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France.

出版信息

Antimicrob Agents Chemother. 2002 Feb;46(2):566-9. doi: 10.1128/AAC.46.2.566-569.2002.

DOI:10.1128/AAC.46.2.566-569.2002
PMID:11796380
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC127075/
Abstract

Pseudomonas aeruginosa clinical isolate CY-1, which was resistant to ceftazidime, harbored a conjugative ca. 250-kb plasmid that contained a class 1 integron with two gene cassettes encoding OXA-32, an OXA-2- type beta-lactamase, and the aminoglycoside acetyltransferase AAC(6')Ib(9). OXA-32 differed from OXA-2 by an Leu169Ile amino acid substitution (class D numbering). Site-directed mutagenesis established that Ile169 is responsible for resistance to ceftazidime but not to cefotaxime.

摘要

铜绿假单胞菌临床分离株CY-1对头孢他啶耐药，它含有一个约250kb的接合质粒，该质粒包含一个1类整合子，带有两个基因盒，分别编码OXA-32（一种OXA-2型β-内酰胺酶）和氨基糖苷乙酰转移酶AAC(6')Ib(9)。OXA-32与OXA-2在第169位氨基酸由亮氨酸突变为异亮氨酸（D类编号）。定点诱变表明，第169位异亮氨酸导致对头孢他啶耐药，但对头孢噻肟不耐药。