三种非氟喹诺酮类药物对代表性细菌分离株的体外活性。
In vitro activities of three nonfluorinated quinolones against representative bacterial isolates.
作者信息
Barry A L, Fuchs P C, Brown S D
机构信息
The Clinical Microbiology Institute, Wilsonville, Oregon 97070, USA.
出版信息
Antimicrob Agents Chemother. 2001 Jun;45(6):1923-7. doi: 10.1128/AAC.45.6.1923-1927.2001.
In vitro susceptibility tests were performed to document the inhibitory activities of three nonfluorinated quinolone (NFQ) compounds (PGE 9262932, PGE 9509924, and PGE 4175997) compared to those of ciprofloxacin, levofloxacin, and trovafloxacin against 3,030 bacterial isolates. The spectra of the NFQ agents included most gram-positive species as well as quinolone-susceptible Enterobacteriaceae. Ciprofloxacin-resistant, methicillin-resistant Staphylococcus aureus strains were inhibited by the NFQ series at < or =1.0 microg/ml. The NFQ compounds were not very active against Pseudomonas aeruginosa and most other nonfermentative gram-negative bacilli. Against other species, the potency of the NFQ agents was similar to that of trovafloxacin. Continued investigation of the NFQ compounds seems to be warranted.
进行了体外药敏试验，以记录三种非氟喹诺酮（NFQ）化合物（PGE 9262932、PGE 9509924和PGE 4175997）与环丙沙星、左氧氟沙星和曲伐沙星相比，对3030株细菌分离株的抑制活性。NFQ药物的抗菌谱包括大多数革兰氏阳性菌以及对喹诺酮敏感的肠杆菌科细菌。耐环丙沙星、耐甲氧西林金黄色葡萄球菌菌株在浓度≤1.0微克/毫升时被NFQ系列抑制。NFQ化合物对铜绿假单胞菌和大多数其他非发酵革兰氏阴性杆菌活性不强。对于其他菌种，NFQ药物的效力与曲伐沙星相似。似乎有必要继续对NFQ化合物进行研究。
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