Dette G A, Knothe H
Abteilung für Medizinische Mikrobiologie, Johann Wolfgang Goethe-Universität, Frankfurt/Main.
Arzneimittelforschung. 1989 Aug;39(8):832-5.
Lomefloxacin (1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4- oxoquinoline-3-carboxylic acid monohydrochloride, SC-47111) is a broad-spectrum antibiotic of the 4-quinolone group. In this comparative study the antimicrobial in-vitro activity of lomefloxacin was tested against 863 gram-negative and 415 gram-positive strains from fresh clinical isolates. As comparative agents ciprofloxacin, norfloxacin and ofloxacin were used. The minimal inhibitory concentrations were determined by means of a serial dilution with the agar-dilution procedure. Lomefloxacin showed an antibacterial efficacy comparable to other quinolones. Ciprofloxacin in general was two-fold dilutions more active. No cross-resistance with beta-lactamase producing-methicillin resistant or aminoglycoside-, tetracycline-, chloramphenicol- and co-trimoxacol-resistant strains could be found. Lomefloxacin showed in this study a broad antimicrobial activity. The clinical utilities of this new fluoroquinolone will depend on the pharmacokinetic properties and the adverse event profile.
洛美沙星（1-乙基-6,8-二氟-1,4-二氢-7-(3-甲基-1-哌嗪基)-4-氧代喹啉-3-羧酸盐酸盐，SC-47111）是4-喹诺酮类的一种广谱抗生素。在这项比较研究中，测试了洛美沙星对来自新鲜临床分离株的863株革兰氏阴性菌和415株革兰氏阳性菌的体外抗菌活性。使用环丙沙星、诺氟沙星和氧氟沙星作为对照药物。通过琼脂稀释法进行系列稀释来测定最低抑菌浓度。洛美沙星显示出与其他喹诺酮类相当的抗菌效力。一般来说，环丙沙星的活性高两倍稀释度。未发现与产β-内酰胺酶的耐甲氧西林菌株或耐氨基糖苷类、四环素类、氯霉素类和复方新诺明菌株存在交叉耐药性。在这项研究中，洛美沙星显示出广泛的抗菌活性。这种新型氟喹诺酮类药物的临床应用将取决于其药代动力学特性和不良事件情况。
