Pentagastrin increases phenylalanine and decreases histidine incorporation to proteins of rat stomach.

Female rats were treated with L-phenylalanine-14C or L-histidine-14C, 20 mug/kg i.p. one hour before receiving pentagastrin 250 mug/kg s.c. Sixty minutes after injection of pentagastrin the incorporation of L-phenylalanine-14C into the proteins of the squamous and fundic portions of the stomach was significantly increased respectively by 18 and 17.5%. On the contrary, the uptake of Lhistidine-14C into the proteins of the squamous (-24%), fundic (-18% and duodenal (-16%) regions was significantly decreased. Incorporation of histidine and phenylalanine into the proteins of the pylorus was not significantly affected by pentagastrin.