Collins A R, Horváthová E
Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, U.K.
Biochem Soc Trans. 2001 May;29(Pt 2):337-41. doi: 10.1042/0300-5127:0290337.
Estimates of background levels of oxidative base damage in human white blood cells vary enormously, from 300 down to 0.4 molecules of 8-oxoguanine per 10(6) guanines. An EC-funded Concerted Action, the European Standards Committee on Oxidative DNA Damage, is currently attempting to resolve the discrepancy and to agree a realistic estimate of basal endogenous oxidation. Oxidation of lymphocyte DNA is a useful marker of oxidative stress, and this can be decreased by supplementation with pure antioxidants or with foods rich in antioxidants. The steady-state level of DNA oxidation is ultimately controlled by the process of DNA repair; the extent to which this varies between individuals has yet to be established.
人体白细胞中氧化性碱基损伤的背景水平估计值差异极大，从每10⁶个鸟嘌呤中有300个到0.4个8-氧代鸟嘌呤分子不等。一项由欧盟资助的联合行动，即欧洲氧化性DNA损伤标准委员会，目前正试图解决这一差异，并就基础内源性氧化的实际估计值达成一致。淋巴细胞DNA的氧化是氧化应激的一个有用指标，补充纯抗氧化剂或富含抗氧化剂的食物可以降低这种氧化。DNA氧化的稳态水平最终由DNA修复过程控制；个体之间这种变化的程度尚未确定。
