Walford R L, Gossett T, Smith G S, Zeller E, Wilkinson J
Tissue Antigens. 1975 Apr;5(3):196-204. doi: 10.1111/j.1399-0039.1975.tb01214.x.
Certain otherwise well-definedHL-Atyping sera contain extra antibodies which do not appear to be closely related to known HL-A specificites and which react in the cytotoxic test with chronic lymphaticleukemia lymphocytes but not with normal lymphocytes. Despite nonreactivity in thecytotoxic test, absorption studies show that the antigenic factors are well represented onnormal lymphocytes. Based on cross-absorption experiments using both normal andleukemic cells, followed by back-testing with the cytotoxic test against a leukemiccell panel, evidence is presented suggesting the existence of a complex, probablymultiple allelic system on human lymphoid cells which appears distinct from the, HL-Asystem, and is definable by serologic techniques.
某些在其他方面定义明确的HL - A分型血清含有额外的抗体，这些抗体似乎与已知的HL - A特异性没有密切关系，并且在细胞毒性试验中与慢性淋巴细胞白血病淋巴细胞发生反应，但不与正常淋巴细胞发生反应。尽管在细胞毒性试验中无反应，但吸收研究表明，这些抗原因子在正常淋巴细胞上有良好的表现。基于使用正常细胞和白血病细胞进行的交叉吸收实验，随后用针对白血病细胞系的细胞毒性试验进行回测，有证据表明人类淋巴细胞上存在一个复杂的、可能是多个等位基因的系统，该系统似乎与HL - A系统不同，并且可以通过血清学技术进行定义。
