Hassan E A, Creatsas G K, Diakomanolis E S, Sakellaropoulos G G, Rodolakis A J, Konidaris S D, Michalas S P
Colposcopy Units, 1st and 2nd Departments of Obstetrics and Gynecology, University of Athens, Athens, Greece.
J Pediatr Adolesc Gynecol. 2001 Feb;14(1):35-8. doi: 10.1016/s1083-3188(00)00081-4.
To evaluate the colposcopic findings of cervical alterations in the young sexually active female.
DESIGN, SETTING, PARTICIPANTS: Colposcopic examination and follow-up of 51 young sexually active females aged 15-20 yr was conducted due to abnormal cytology or a suspicious abnormality of the cervix. The study was conducted at the Colposcopy Units of the 1(st) and 2(nd) Departments of Obstetrics and Gynecology, University of Athens, Greece. ONTERVENTIONS: Colposcopic examination, LEEP, conization.
Biopsy, human papillomavirus (HPV) typing.
Colposcopic examinations were within normal limits in 8 of 51 (15.7%) cases. Cervical alterations were related to HPV infection in 14 cases (27.4%), to cervical intraepithelial neoplasia (CIN) I in 15 (29.4%) cases, to CIN II in 13 (25.5%) cases, and to CIN III in 1 (2.0%) case. Of all CIN I cases, 8 of 15 (53.3%) were HPV positive, and HPV type 11, 16, 18, 31, 33, and 11& 16 were found. In CIN II cases, 5 of 13 (38.4%) were HPV positive, and HPV type 11, 16, 18, and 11 & 31 were found. In the CIN III case, only HPV type 16 was found.
Our findings strongly confirm the necessity of obtaining cervicovaginal smears on all sexually active gynecologic and obstetric teenage patients. Colposcopy plays a major role in the evaluation of the cervix and in the treatment that should be given for any individual CIN lesion.
评估年轻性活跃女性宫颈病变的阴道镜检查结果。
设计、地点、参与者：对51名年龄在15至20岁的年轻性活跃女性进行阴道镜检查及随访，这些女性因细胞学异常或宫颈可疑异常而接受检查。研究在希腊雅典大学第一和第二妇产科阴道镜检查科室进行。干预措施：阴道镜检查、利普刀手术、锥形切除术。
活检、人乳头瘤病毒（HPV）分型。
51例中有8例（15.7%）阴道镜检查结果正常。14例（27.4%）宫颈病变与HPV感染有关，15例（29.4%）与宫颈上皮内瘤变（CIN）I有关，13例（25.5%）与CIN II有关，1例（2.0%）与CIN III有关。在所有CIN I病例中，15例中有8例（53.3%）HPV呈阳性，发现HPV 11、16、18、31、33型以及11和16型。在CIN II病例中，13例中有5例（38.4%）HPV呈阳性，发现HPV 11、16、18型以及11和31型。在CIN III病例中，仅发现HPV 16型。
我们的研究结果有力地证实了对所有性活跃的妇产科青少年患者进行宫颈阴道涂片检查的必要性。阴道镜检查在宫颈评估以及针对任何个体CIN病变应给予的治疗中起着主要作用。
