Henze G, Lautner H, Neubrand W, Werner E
JPEN J Parenter Enteral Nutr. 1979 Jul-Aug;3(4):231-4. doi: 10.1177/014860717900300405.
Eight preterm infants, five with postnatal asphyxia, as well as two hypotrophic neonates and one term infant with severe postnatal asphyxia (mean birth weight 2300 g) were fed, in addition to oral nutrition, partially parenterally with glucose solution and mother's-milk-adapted amino acid solution during their first three days of life. By increasing protein supplies with a parenteral share of more than 50% during the three days, the nitrogen balances were positive on all days, although the calories supplied were far below the postulated optimum. On days 2 and 3, nitrogen retention was about 60% of the supply. Every 4 hrs after discontinuation of the 16 hr amino acid infusion, the amino acid levels in the plasma were examined by column chromatography. The resulting mean values did not show any imbalances of amino acid homeostasis. The maximum mean loss in weight of the present groups was 4% of the birth weight during the first 10 days of life and thus equalled the loss in weight of normal healthy preterms. Clinical and chemical parameters did not reveal any disadvantageous side effects of partial parenteral nutrition.
八名早产儿，其中五名有产后窒息，还有两名低体重新生儿和一名足月产且有严重产后窒息的婴儿（平均出生体重2300克），在出生后的头三天，除了口服营养外，还通过静脉部分输注葡萄糖溶液和适合母乳的氨基酸溶液进行喂养。在这三天里，通过将静脉营养份额提高到50%以上来增加蛋白质供应，尽管所提供的热量远低于假定的最佳值，但氮平衡在所有日子里都是正向的。在第2天和第3天，氮潴留约为供应量的60%。在16小时的氨基酸输注停止后，每4小时通过柱色谱法检测血浆中的氨基酸水平。所得平均值未显示氨基酸稳态有任何失衡。本研究组在出生后前10天体重的最大平均减轻量为出生体重的4%，因此与正常健康早产儿的体重减轻量相当。临床和化学参数未显示部分肠外营养有任何不利的副作用。
