Kim Y K, Park H S, Kim H Y, Jee Y K, Son J W, Bae J M, Lee M H, Cho S H, Min K U, Kim Y Y
Department of Internal Medicine, Seoul National University College of Medicine, Korea.
Clin Exp Allergy. 2001 Apr;31(4):582-9. doi: 10.1046/j.1365-2222.2001.01056.x.
Recent investigations have demonstrated that spider mites are important allergens in the development of asthma in fruit-cultivating farmers.
The aim of this study was to evaluate the sensitization rate to the citrus red mite (Panonychus citri) in children living in rural areas, and to determine the allergenic cross-reactivity with other mites.
A total of 7254 children (ages 7-15 years) living in rural areas were enrolled, and each subject was evaluated by a questionnaire and a skin prick test. Allergenic cross-reactivity was evaluated by ELISA inhibition tests.
The most common sensitizing allergens were house dust mites, followed by citrus red mite and cockroach. High serum-specific IgE bindings to the citrus red mite were detected in 21 of 100 randomly selected subjects. The prevalence of asthma was higher among those with positive skin responses to the citrus red mite than with negative skin responses to this mite. ELISA inhibition tests showed that IgE bindings to this mite were minimally inhibited with additions of domestic mites.
Spider mites such as the citrus red mite may be important outdoor allergens among children living in rural areas, and spider mite-derived allergens have unique allergenic determinants compared with domestic mites.
最近的调查表明，叶螨是水果种植农民哮喘发病过程中的重要过敏原。
本研究旨在评估农村地区儿童对柑橘全爪螨的致敏率，并确定其与其他螨类的过敏原交叉反应性。
共纳入7254名居住在农村地区的7至15岁儿童，每位受试者均通过问卷调查和皮肤点刺试验进行评估。通过酶联免疫吸附抑制试验评估过敏原交叉反应性。
最常见的致敏过敏原是屋尘螨，其次是柑橘全爪螨和蟑螂。在随机选择的100名受试者中，有21人检测到血清中针对柑橘全爪螨的特异性IgE结合水平较高。对柑橘全爪螨皮肤反应呈阳性的儿童中哮喘患病率高于对该螨皮肤反应呈阴性的儿童。酶联免疫吸附抑制试验表明，添加屋尘螨后，针对该螨的IgE结合受到的抑制作用最小。
柑橘全爪螨等叶螨可能是农村地区儿童重要的室外过敏原，与屋尘螨相比，叶螨衍生的过敏原具有独特的过敏原决定簇。
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