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单剂量尾骶部注射曲马多、曲马多联合布比卡因及布比卡因用于儿童术后镇痛的比较

A comparison of single dose caudal tramadol, tramadol plus bupivacaine and bupivacaine administration for postoperative analgesia in children.

作者信息

Gunduz M, Ozcengiz D, Ozbek H, Isik G

机构信息

Department of Anaesthesiology, Cukurova University Faculty of Medicine, 01330 Balcali Adana, Turkey.

出版信息

Paediatr Anaesth. 2001 May;11(3):323-6. doi: 10.1046/j.1460-9592.2001.00647.x.

Abstract

BACKGROUND

Our aim was to compare the effect of single dose caudal tramadol, tramadol plus bupivacaine and bupivacaine on the management of postoperative pain in children.

METHODS

Sixty-three children in ASA groups I-II, between the ages of 1 and 5 were evaluated for postoperative pain randomly divided into three groups as follows: In group T, only tramadol was given caudally; in group TB, tramadol-bupivacaine was given caudally; in group B, bupivacaine was given alone. Pain was evaluated by using the paediatric objective pain scale (POPS). Sedation was evaluated with a 5-point test. There were no differences with age, weight, haemodynamic and respiratory parameters between groups.

RESULTS

For 24 h postoperatively, the POPS value showed no statistically significant difference among groups (P > 0.05). Postoperative analgesia was maintained for 24 h. Nausea and vomiting was found to be higher in the tramadol group than in the bupivacaine group and tramadol-bupivacaine group (P < 0.001 and P < 0.01, respectively).

CONCLUSION

Tramadol used caudally is as effective as bupivacaine in the management of postoperative pain in children and the addition of tramadol to bupivacaine, when both drugs were administered caudally, did not prolong the duration of action of bupivacaine and is a safe agent in children.

摘要

背景

我们的目的是比较单次剂量的尾骶部曲马多、曲马多加布比卡因和布比卡因对儿童术后疼痛管理的效果。

方法

对63例年龄在1至5岁、ASA分级为I-II级的儿童进行术后疼痛评估,随机分为以下三组:T组仅给予尾骶部曲马多;TB组给予尾骶部曲马多-布比卡因;B组仅给予布比卡因。采用儿科客观疼痛量表(POPS)评估疼痛。用5分制测试评估镇静情况。各组之间在年龄、体重、血流动力学和呼吸参数方面无差异。

结果

术后24小时,各组的POPS值无统计学显著差异(P>0.05)。术后镇痛维持24小时。发现曲马多组的恶心和呕吐发生率高于布比卡因组和曲马多-布比卡因组(分别为P<0.001和P<0.01)。

结论

尾骶部使用曲马多在儿童术后疼痛管理中与布比卡因效果相同,当两种药物均尾骶部给药时,曲马多与布比卡因联合使用并不延长布比卡因的作用时间,且对儿童是一种安全的药物。

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