Howard P C, Eppley R M, Stack M E, Warbritton A, Voss K A, Lorentzen R J, Kovach R M, Bucci T J
National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.
Environ Health Perspect. 2001 May;109 Suppl 2(Suppl 2):277-82. doi: 10.1289/ehp.01109s2277.
Fumonisin B1 (FB1) is a mycotoxin isolated from Fusarium fungi that contaminate crops worldwide. A previous study demonstrated that FB1 promoted preneoplastic foci in initiated rats and induced hepatocellular carcinomas in BD IX rats at 50 parts per million (ppm), but fundamental dose-response data were not available to assist in setting regulatory guidelines for this mycotoxin. To provide this information, female and male F344/N/Nctr BR rats and B6C3F1 Nctr BR mice were fed for two years a powdered NIH-31 diet containing the following concentrations of FB1: female rats, 0, 5, 15, 50, and 100 ppm; male rats, 0, 5, 15, 50, and 150 ppm; female mice, 0, 5, 15, 50, and 80 ppm; male mice, 0, 5, 15, 80, and 150 ppm. FB1 was not tumorigenic in female F344 rats with doses as high as 100 ppm. Including FB1 in the diets of male rats induced renal tubule adenomas and carcinomas in 0/48, 0/40, 9/48, and 15/48 rats at 0, 5, 15, 50, and 150 ppm, respectively. Including up to 150 ppm FB1 in the diet of male mice did not affect tumor incidence. Hepatocellular adenomas and carcinomas were induced by FB1 in the female mice, occurring in 5/47, 3/48, 1/48, 19/47, and 39/45 female mice that consumed diets containing 0, 5, 15, 50, and 80 ppm FB1, respectively. This study demonstrates that FB1 is a rodent carcinogen that induces renal tubule tumors in male F344 rats and hepatic tumors in female B6C3F1 mice.
伏马菌素B1（FB1）是一种从镰刀菌中分离出的霉菌毒素，这种真菌会污染全球的农作物。先前的一项研究表明，FB1能促进起始大鼠的癌前病灶形成，并在BD IX大鼠中以百万分之五十（ppm）的剂量诱发肝细胞癌，但尚无基本的剂量反应数据来协助制定该霉菌毒素的监管指南。为了提供这些信息，给雌性和雄性F344/N/Nctr BR大鼠以及B6C3F1 Nctr BR小鼠喂食含以下浓度FB1的粉状NIH-31饲料，持续两年：雌性大鼠，0、5、15、50和100 ppm；雄性大鼠，0、5、15、50和150 ppm；雌性小鼠，0、5、15、50和80 ppm；雄性小鼠，0、5、15、80和150 ppm。高达100 ppm剂量的FB1对雌性F344大鼠无致癌性。在雄性大鼠的饲料中添加FB1，分别在0、5、15、50和150 ppm剂量组的大鼠中诱发肾小管腺瘤和癌，发生率分别为0/48、0/40、9/48和15/48。在雄性小鼠的饲料中添加高达150 ppm的FB1对肿瘤发生率无影响。FB1在雌性小鼠中诱发肝细胞腺瘤和癌，分别在食用含0、5、15、50和80 ppm FB1饲料的5/47、3/48、1/48、19/47和39/45只雌性小鼠中出现。本研究表明，FB1是一种啮齿动物致癌物，可在雄性F344大鼠中诱发肾小管肿瘤，在雌性B6C3F1小鼠中诱发肝脏肿瘤。
