Voss K A, Chamberlain W J, Bacon C W, Herbert R A, Walters D B, Norred W P
Toxicology and Mycotoxin Research Unit, Agricultural Research Service, USDA, Athens, Georgia 30613.
Fundam Appl Toxicol. 1995 Jan;24(1):102-10. doi: 10.1006/faat.1995.1012.
Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium moniliforme, a common fungus which occurs naturally on corn, and other Fusarium species. FB1 and other fumonisins are now recognized as having potentially important animal and human health implications. However, few toxicological data are currently available. Male and female B6C3F1 mice and Fischer 344 rats were fed diets containing 0, 1, 3, 9, 27, or 81 ppm FB1 (> or = 98% purity) for 13 weeks. No differences in behavior or appearance, body weight or food consumption between control and FB1-fed groups were found. In mice, hepatopathy and altered serum chemical profiles indicative of hepatotoxicity were found in females fed the 81 ppm diet. No adverse effects were found in female mice fed < or = 27 ppm FB1 or in male mice at any dietary level studied. In rats, nephrosis involving the outer medulla was found in males fed > or = 9 ppm and, to a lesser degree, in females fed 81 ppm FB1, while decreased kidney weight was found in both sexes at dietary levels > or = 9 ppm FB1. Although the liver is a target organ of FB1 in rats, hepatotoxicity was not found in rats fed diets containing up to 81 ppm FB1 for 90 days. Thus, FB1 was toxic to both species following subchronic oral exposure, although significant interspecies differences in the no observed effect levels and organ-specific responses were found.
伏马菌素B1（FB1）是由串珠镰刀菌产生的一种霉菌毒素，串珠镰刀菌是一种常见的真菌，天然存在于玉米及其他镰刀菌属物种上。FB1和其他伏马菌素目前被认为对动物和人类健康具有潜在的重要影响。然而，目前可用的毒理学数据很少。将雄性和雌性B6C3F1小鼠以及Fischer 344大鼠喂食含0、1、3、9、27或81 ppm FB1（纯度≥98%）的饲料，持续13周。在对照组和喂食FB1的组之间，未发现行为或外观、体重或食物消耗量有差异。在喂食81 ppm饲料的雌性小鼠中，发现了肝病以及表明肝毒性的血清化学指标变化。在喂食≤27 ppm FB1的雌性小鼠或任何研究饮食水平的雄性小鼠中，未发现不良反应。在雄性大鼠中，当喂食≥9 ppm时发现涉及外髓质的肾病，在喂食81 ppm FB1的雌性大鼠中程度较轻，而在饮食水平≥9 ppm FB1时，两性均发现肾脏重量减轻。尽管肝脏是大鼠中FB1的靶器官，但在喂食含高达81 ppm FB1的饲料90天的大鼠中未发现肝毒性。因此，亚慢性口服暴露后，FB1对两种物种均有毒性，尽管在未观察到影响的水平和器官特异性反应方面发现了显著的种间差异。
