Dow L, Fowler L, Phelps L, Waters K, Coggon D, Kinmonth A L, Holgate S T
Care of the Elderly, Division of Medicine, University of Bristol, Bristol, UK.
Thorax. 2001 Jun;56(6):472-6. doi: 10.1136/thorax.56.6.472.
A study was undertaken to estimate the prevalence of untreated asthma in older adults.
A cross sectional population based survey of 6000 men and women aged 65 years and over was performed in 21 general practices in north Bristol, south west England. The main outcome measure was untreated asthma as defined by a two stage process comprising a respiratory questionnaire (symptoms suggestive of asthma or doctor diagnosed asthma not receiving respiratory treatment) followed by lung function tests (significant reversibility following bronchodilators or corticosteroids and/or significant within day variability in peak expiratory flow).
4792 of the 6000 participants (80%) completed the respiratory questionnaire and, of those not receiving respiratory treatment, 55 reported a previous doctor diagnosis of asthma and a further 696 had symptoms suggestive of asthma. Lung function testing in 280 of 501 randomly selected individuals from these groups resulted in 38 being defined as having asthma and an estimated population prevalence for untreated asthma of 2.4% (95% CI 1.6% to 3.6%) in men and 1.2% (95% CI 0.7% to 2.1%) in women. Most subjects (84%) with untreated asthma had moderate or severe disease. Untreated asthma was most common in individuals with doctor diagnosed asthma (21%) and those with breathlessness or wheeze (13-20%).
Untreated asthma in the elderly is a common and important problem. Opportunistic use of appropriate lung function tests in older people with a history of doctor diagnosed asthma or wheeze or breathlessness at rest could identify untreated asthmatics who might benefit from treatment.
开展了一项研究以估计老年人中未治疗哮喘的患病率。
在英格兰西南部布里斯托尔北部的21家普通诊所,对6000名65岁及以上的男性和女性进行了基于人群的横断面调查。主要结局指标是未治疗哮喘,其定义为一个两阶段过程,包括呼吸问卷(提示哮喘的症状或医生诊断为哮喘但未接受呼吸治疗),随后进行肺功能测试(支气管扩张剂或皮质类固醇治疗后有显著可逆性和/或呼气峰值流量日内有显著变异性)。
6000名参与者中有4792人(80%)完成了呼吸问卷,在未接受呼吸治疗的人中,55人报告曾被医生诊断为哮喘,另有696人有提示哮喘的症状。对这些组中随机选取的501人中的280人进行肺功能测试,结果38人被定义为患有哮喘,估计未治疗哮喘的人群患病率男性为2.4%(95%可信区间1.6%至3.6%),女性为1.2%(95%可信区间0.7%至2.1%)。大多数未治疗哮喘患者(84%)患有中度或重度疾病。未治疗哮喘在医生诊断为哮喘的个体中最常见(21%),在有呼吸急促或喘息的个体中也较为常见(13 - 20%)。
老年人中未治疗哮喘是一个常见且重要的问题。对有医生诊断哮喘病史或休息时喘息或呼吸急促的老年人机会性地使用适当的肺功能测试,可识别出可能从治疗中获益的未治疗哮喘患者。